Substitution treatment with buprenorphine was associated with both higher adherence rates (27.3% vs
8.1%, P = .04) and higher sustained viral response rates (83.3% vs
48.9%, P = .002), compared with methadone use.
In multivariate analyses, adherence to treatment (P < .0001) and buprenorphine use (P = .007) were independently associated with a greater chance of sustained virologic response.
Buprenorphine may be a more effective treatment for opioid withdrawal, Dr.