If taken as prescribed, that should be the only side effect that's obvious. Long term use seems to have a variety of side
. Memory is a little effected, teeth, constipation
, trouble urinating, and a numb, zombie like effect have been reported. My close friend uses sub for pain, for 5 yrs now. He was taking 1800mgs of oxy before that, but he is doing well and a functioning member of society. i've noticed he is not totally present, but he is doing fine and the subs work for his pain.