stopping peg intron therapy

I was taking Incivek, ribaviran and peg intron. I had a pre surgery physical today and my EKG came up slightly abnormal than the previous one I had before treatment. My question is can the aftermath of these drugs affect the heart? I'm supposed to have a meniscus repair done on the 27th and my cardiologist suggests I have a CT scan of my heart. Any insight would be appreciated.

s weight is 60 kg and dr. recommend her 80 microgram dose of peg-intron injections with 400mg Virex capsulse. While I have read on Peg-intron literature that its dose is given by weight. For monotherapy use 0.5 microgram/kg/week. For combination therapy 1.5 microgram/kg/week...i think my mother case is combination therapy (injections + capsules).And for 60 kg weight injection dose should be 100 micrograms. Please advise.

SVR for Peg-Intron plus Rebetol combination therapy is 41% for genotype 1, and 82% for genotypes 2 through 6. Peg-Intron is a reconstituted powder that is dosed according to a person's weight. Roche’s Pegasys plus Copegus: SVR for Pegasys plus Copegus combination therapy is 44-51% for genotype 1, and 70-82% for genotypes 2 through 6. Pegasys is a ready-made solution that is dosed at 180µg regardless of a person's weight.

Well, if your HBV DNA wasn't all that high before your Peg Intron, it's not surprising that you would go UND. As long as you stay HBV DNA UND on Peg Intron, your HepB is being managed well. It's obviously the desired outcome. Here's the thing, you have a timeframe for Peg Intron for HCV treatment. I think your doc will stop Peg Intron based on HCV because there's no timeframe for HBV.

I asked my doctor for pegasys over peg intron. He addressed my concerns and told me sx's for me would be similar with either drug and kinetics were similar for both with regard to initial suppression of the virus. I had read about peaks and troughs with peg intron. He said that was dated info. Ok, so we decided to stay with peg intron. Now...about dosage. Can anyone explain why pegasys is one dose fits all and peg intron is weight based? I will get 80 mcg with weight at 114 lbs.

I just took my first shot of Peg Intron Friday night, and I got pretty sick, but thank God after I stayed in bed the next day I felt better. Do these reactions happen every time you inject it or does your body eventually get use to it. Also my viral load is only 300 and I have genotype 1. Can anyone give me more information about my Hep C being cured after this treatment or does it ever get cured?

I have treated 5 or 6 times, cleared only to relapse each time. Have tried intron A , peg-intron, Pegasys and 72 weeks of infergen and until 6 months ago have been on maintenance therapy. I was a stage 4 with a enlarged spleen. Last biopsy and mri came back a stage 3 and a normal size spleen.

t have as good as a viral load drop as I did with the Peg-Intron. I had more sides with the Peg-Intron but a bigger viral load drop. I hope for you, that all the rest of your treatment day are sides free.

He uses Pegasys and my GI doctor (whom I love) uses peg-intron. My question for all peg-intron users is how bad have your sx been? The doctor I saw today said pegasys seems to have less sx, but of course not all people react the same way. I love my GI doctor and want to treat with him, but am I making a mistake by going Peg-Intron? Thanks for your input. My stats: 26 years old, really healthy, active female, geno 3a, VL 949,000. No biopsy done Thanks!

My husband who has been on the Peg Intron therapy for 17 weeks is suddenly experiencing nausea. His side effects have been mininal to date, but is it possible this is being caused by the medication? Can this side effect appear out of nowhere at this point in time?

s shorter and linear-chain PEG, Peg Intron has a half-life of 30-50 hours. (Note that NPIA or non-pegylated interferon alfa has a half-life of only 3-5 hours.) 3) …multiple-dose ribavirin half-life (298 hours) is considerably longer than the single-dose half-life (79 hours) Questions: #1 What extent does RIBA prolong the half-life of the Pegasys and the Peg Intron? #2 Am I phrasing the question right? Is this how it works?

As a result of its controlled-release mechanism, Locteron was dosed half as frequently as PEG-Intron. PEG-Intron is one of two currently marketed pegylated interferon products for the treatment of hepatitis C, a market that currently exceeds $2.5 billion in worldwide sales. Additional results from SELECT-2 demonstrated the substantial tolerability advantages of Locteron.

Eight years ago when I took the SOC I was told that Pegasys, which was relatively new then was better than the Peg intron which had been available for some time. I was also told by my doctor who was treating a large number of patients at his clinic that he had observed that the Pegasys was more easily tolerated than the other drug.

Just confirm that she had used Peg-Intron (pegelated) or Intron (simple interferone) previously. I think your mom should consult with good specilaist as he/she will first assess the condition of your mom whether she is in condition to support Treatment or not. seems to be from Pakistan or india ???

The only thing I might add,is that this is my husbands 4th try and he has used all the available interferons. The Peg-intron was by far the hardest for him. Pegasys was much more tolerable in his case. If your mom used Peg-intron, she maybe could try Pegasys with one of the new protease inhibitors. You have to have a decent interferon response for it to work though. Hopefully your mom's health will hold out for a non-interferon solution. I hope something will work out for your mom.

Sorry it was Peg intron rebetron 600 600-3/05 ml kit and 150 .5 ml and 150 .5 ml Peg intron that is exactly what they sent to the insurance company. I was talking to my sister she said at least 800 of rebetol aday.

I have done all 3 therapies, Peg-Intron,Infergen,and Pegasys(102 weeks).I could clear for 5 or 6 mths. on therapy and then it would blast me again. The Hep C has brought along Neuropathy, Cryoglobulinema, and Vasculitis. I have taken 4 infusions of Rituxin,(which is the normal dosage to begin with)),hoping to control the cryo and they are now having me take 1 infusion treatment of Rituxin, every 3 mths. So possibly the Reclast is a maintainence therapy also?

I found out two weeks ago that the HCV virus is back and so I have begun Week 1 of treatment. My doctor has prescribed Peg-Intron since I had so many side-effects with Pegasys. Does anyone have any experience with both Pegasys and Peg-Intron? I am genotype 1, stage 3, grade 0-1. I took my first injection a few days ago and Peg-Intron completely wiped me out with feel and aches and pains but I am trying to accept what is to come and hope that my experience with the first tratment will help me.

I was advised to reduce my Peg Intron due to low platelets. I accidentally did 150 mcg. in week five due to getting the wrong Redipen then in week six I started reducing. Platelets bounced back up around 70 so I've kept my dose at 96 mcg. My weight is down to 165 lbs. from 175 lbs. so I am now injecting the recommended dose of Peg Intron. This took me about two hours to do this morning so I must be feeling better on my 2nd day off Incivek.

I finished treatment with Peg-Intron and Ribavirin in 2007, after a 24 week course. I acheived non-detectable levels of HCVRNA after 4 weeks of treatment. I have, however, since relapsed. My current doctor would like to retreat with Infergen and Ribavirin, with the belief that the HCV virus has developed some form of immunity to the pegylated interferon.

So, double-dosing is one such card, but also is switching Pegs -- perhaps to Infergen, as opposed to Peg Intron. Remember, you were still detectible with Peg Intron at week 12 last time Another card is taking a look at your ribavirn/hemoglobin situation to make sure you're on a maximum, but reasonable dose for your body weight and hemoglobin response. Perhaps with the help of Procrit (epo).

"180" is the standard dosage for Pegasys. You state you're on "Peg Intron" which is made by a different manufacturer and dosed differently by weight. The most common forumulations of Peg Intron need to be refrigerated and I therefore assume so does yours since it was shipped in a styrofoam container. The ribavirin can be stored at room temperature. Like in your case, my ribavirin was also shipped in the styrofoam along with the peg.

The SVR rate for geno 1's using Intron A (pre-peg) with ribavirin was 14%.

My experience was that Pegasys was much much easier to tolerate than was Peg-Intron. I treated with both interferons and Pegasys was literally a walk in the park compared to Peg-Intron. I think the efficacy is pretty much equal with Pegasys perhaps having a slight edge. It was the tolerability of Pegasys that enabled me to extend my treatment duration and achieve SVR.

I got two letters today, one saying that I am denied Peg-Intron beacuse I did not try pegasys. And the second said I was denied Ribaviron because that is only approved for people with hep C using peg-intron or pegasys with geno 2 or 3. HELLO INSURANCE CO....I'm HCV and geno 3!!!! SOOOO FRUSTRATING! Sorry, needed to vent. Any advice would be great! Thanks!

Stopping peg intron therapy

Common Questions and Answers about Stopping peg intron therapy

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