I've had just about every side effect in the book and then some, and I haven't needed any opiate based pain
, acetaminophen, naproxen, anti-histamines, moisturizing lotions, sleep aids (lunesta), anti-depressants and prednisone? Saure. But opiates? Nah.
Treatment usually causes fatigue, exhaustion, irritability, insomnia, mental confusion, depression, hair loss, itching, skin rash, dandruff, psoriasis, anemia, neutropenia etc etc.