Intravenous Solumedrol, the drug often used
to cut short severe MS flares, is given for 3
to 5 days at 1000 mg per day. This is
equivalent to 1250 mg per day of oral prednisone. And even after 5 days of this, many doctors, including mine, do not prescribe a taper. Just to put things in perspective...
Those who take prednisone regularly and long term are very likely to need tapering.