However, if persistent, it may indicate nerve damage or certain
disorders of the central nervous system such as restless
leg syndrome, multiple sclerosis, alcoholism, hypothyroidism, medications, or vitamin B12 deficiency, to name a few.
RLS is probably the most frequent movement disorder. Most people with RLS also have periodic limb movement disorder (PLMD), repetitive movements of the toe, foot, and sometimes knee and hip during sleep.