sitagliptin and insulin combination

Statin drugs are not well proven for women, and may contribute to the insulin resistance. Weight loss and very low carb diet may result in independent improvements in lipid profile.

Of the total number of subjects [N=3884] in Phase II and III clinical studies of Sitagliptin, 725 patients were 65 years and over, while 61 patients were 75 years and older. No overall differences in safety or effectiveness were observed between subjects 65 years and over and younger subjects. While this and other clinical experience have not identified differences in responses between the elderly and younger patients, greater sensitivity of some older individuals cannot be ruled out.

When I started on insulin, my doctor gave me a starting ratio of 1 unit of insulin for 15 g of carbs and I then adjusted from there. Adjustment was then done in combination with close monitoring of blood sugars. Ie. I test blood sugar before eating, lets say it is 100. I then eat 45 g of carbs and inject 3 units of insulin before the meal. Test 2 hours after starting to eat and my blood sugar is 140 (my target is < 120 after eating). This tells me that the insulin was not enough.

Three hundred and thirty patients without overt diabetes were treated with combination therapy with (PEG-IFN)/ribavirin for 24 weeks. The IR and beta-cell function were evaluated by homeostasis model assessment of IR (HOMA-IR) and homeostasis model assessment of beta-cell function (HOMA-beta) before treatment. RESULTS: HCV genotype, pretreatment HCV RNA level and pretreatment HOMA-IR, but not HOMA-beta, were independent factors associated with sustained virologic response (SVR).

Type 2 is most often associated with adult-onset and can be a combination of insulin resistance (most often in overweight folks) and also sluggish/impaired insulin production. Type 2s are sometimes treated with insulin, sometimes with oral meds, sometimes both, and always in combination with diet & exercise.

5 (both of which are autoimmune) should use insulin either alone or in combination with appropriate insulin sensitisers (usually metformin) if there is insulin resistance. So what should blood sugar goals be? These are very individual, but should be formulated with consideration that truly normal blood sugars in people who are non-diabetic would consist of fasting blood sugars typically in the low 80s, and post eating blood sugars that rarely if ever exceed 100 (and then not by much).

Hi Bill! I'm a volunteer, not a medical professional, so please check & verify all information received here with your endocrinologist before taking any action. I am the parent of an 18 year old who was diagnosed at the age of 21 months and we've done shots (N&R, Lantus&Humalog), inhaled insulin (did a 2 year study), and currently she's on an insulin pump (& loving it!). My daughter's endo had her on a sliding scale dosage, dependent on her bg reading.

Hello everyone. I'm new to this forum. I've had diabetes type II for 4 years but only recently got the wake up call to take care of it when my blood sugars hit 300 and I was having a hard time staying awake. Up until 3 weeks ago, I was taking 750 mg of metformin ER once a day and a ridiculously high carb diet...everything that is bad for me. 3 weeks ago, I radically changed my eating. I now only eat proteins, vegetables and low sugar fruits. I drink unsweetened iced tea and water.

m asking please if is it possable that if i take the drug sitagliptin it would mean i could reduce the gliclazide and stop the mrtformin my Diabetes is well controlled on the whole but my nurse as requested i increase the glicazide

For the past year, I have been taking Novolog Insulin in combination with Lantus. I have noticed the beginning stages of cellulite around the areas where I give the Novolog injection. I am a 27 year old, juvenile onset diabetic. I am thin for my height and have never had a problem with cellulite until the change in medication. Can this be linked to either of the new insulins that I am taking?

yes, Insulin resistance means there ends up being too much sugr in yur blood and ergo too much uinsulin, and the insulin cancels out the efficacy of the Interferon causing less than optimal VL responses. People with high IR clear later, and SVR far less frequently. "CoWriter" has also compiled a list along with commentary here: http://www.medhelp.org/user_journals/index/568322?

So here is the thing been diabetic for you a few months now and i have been through alot of pills and my doctor hasn't keeps upping them i seen him today and he gave me insulin to take.. but he still wants me to take all the pills is it to much it would be 1000mg metformin 2x a day 100mg januvia a day 4mg glilmapride 2x a day 20units of lantus this seems like so much what do you all think?

Normally, the first step in treatment is oral medication, then dosage increases when patients fasting blood glucose and/or A1c levels elevate. Sometimes a combination of oral medications will be tried. When levels continue to elevate, the next step is to include insulin. Depending on the individual the doctor may remove oral medication and treat only with insulin. Discuss your concerns with your treating doctor.

As a type 2, your ability to process sugars is impaired -- either delayed insulin response and/or some measure of insulin resistance. A regular sode has a lot of simple sugars and each one you drink *does* stress your system. It seems you're able to handle it now, and yet it's in your best long-term interest to develop a new "taste." A typical can of regular soda will have about 40gms of carbo -- all in the form of simple sugars.

If he is having high levels, then the insulin is more important because low insulin will affect the brain and make any stimulant meds ineffective. Education is the best way to approach this in a kid who may be resistant to wanting to deal with it. They might be anxious about social issues with "being different" and are merely reacting to that.

With the pattern described I would assume it to be a combination of an intermediate and long acting insulin. With altered blood sugar levels, either the timing of food intake or the dosage of the long acting insulin or the type of insulin would need to be adjusted. I would suggest consulting your endocrinologist for the same. Hope this is helpful. Take care!

You may wish to discuss premixed insulin, which is a combination of specific proportions of intermediate/long-acting and short acting insulin in one bottle or insulin pen. Btw, Lantus [not to be confused with Apridra] is a long acting insulin not short [fast].

The symptoms could be due to gastric reflux and/or hiatal hernia. Treatment is a combination of drugs to reduce the acid and lifestyle changes. You will need to take a combination of medications like a proton pump inhibitor such as omeprazole, lansoprazole or pantoprazole empty stomach in the morning and an antacid gel after meals for complete relief. Possibility of H pylori infection too should be looked into and a combination antibiotic tried.

They reasoned glucosamine is ten times as powerful as regular glucose thus causing insulin resistance. Insulin resistance can increase fasting blood sugar levels and exacerbate glucose tolerance. Others reported taking glucosamine may not affect blood glucose levels directly, but some evidence from both animal and human studies suggested that it may promote insulin resistance over time. Over what time and when this would occur varies per individual.

I have pcos and have been taking metformin clomid and provera prescribed by my doctor. Ive been on the drugs for three months but still no sign of pregnancy.

Actos belongs in class of diabetes medications called thiazolidinediones. In this class are Avandia and a combination drug Avandamet [Avandia and Metformin]. Rezulin is in this class but not much known about it.

That is totally within the normal range! Even if your doctor anticipates you having insulin resistance and proceeding to develop diabetes you aren't there yet. It would be much more appropriate to recommend a combination of diet for weight loss, cutting carbs and exercise. I'm going to research Insulin Resistance to see if I'm missing something, but that is what I'm seeing now. You need to ask your doctor to explain his treatment and what he is seeing in your medical picture.

I don't understand how alcohol can cause hypoglycemina in diabetics. It seems to me that it would cause hyperglycemia because of the sugar in the alcohol. I just heard a story of an adult who passed out twice because she had wine after taking insulin. Her blood sugar was 175 when she took her insulin and within 15 minutes she was passed out.

I have type 2 and take insulin. I recently had a battle with food poisoning and my glucose went way up(as high as 250) and I was passing ketones, something I haven't done since starting insulin three years ago. When I peed in a cup to test for ketones it smelled like honey. I wasn't eating much at all and what I ate didn't stay down, so -- why the high sugars?

about it, I made the decision to start insulin and it worked out fine. I was scared at first but with the new pens that they have it is really easy.

Sitagliptin and insulin combination

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