Simvastatin half life

Common Questions and Answers about Simvastatin half life

vytorin

Again, only half the story. Red Star is posting the part that is always pointed out by the anti-statin crowd. Here's what they ALWAYS fail to point out, there was no evidence to show a relationship between statins and memory loss, but it was observed in a very, very small percentage of those on statins so they added the warning. Hefre's the link to the announcement from the FDA which you will see they could prove no link, only an observation. http://www.fda.gov/Drugs/DrugSafety/ucm293101.
But surely that's plasma half life? If a statin has a half life of just 11.3 hours for inhibiting activity for HMG-CoA then it's really useless and shouldn't be on the market. You need at least 30-40 hours.
Back in February I woke up to a horrible leg cramp. I was taken to ER and my calcium was half of what it should be. I started in taking my medications regularly my Doctor put me on 40 mg of Simvastatin. Since then I have been really ill. Upset stomach, back pain, leg cramps. I can hardly drive or walk for that matter. Most of all the symptoms that I have read on this I have had. At one point I thought I was dieing. I have had Insomnia and I have sleep apnea too.
I ask because the Lipitor fullpage ads in national magazines say DO NOT BREAK TABLETS and they Lipitor website from Pfizer also says on the meds page DO NOT BREAK TABLETS but my doctor told me to break the 10 mg tabs in half and take just half each day. I wrote to Lipitor's PR department in NYC, a very polite letter, and they so far refuse to answer my emails, preferring to stonewall me, er, pillwall, me, which I do not understand why they would do that. I am a customer. I buy their pills.
simvastatin will help but not as immune modulator but reducing cholesterol for hbsag production, it is also good to note that both sim and alinia are active on all hbv strains so they might prevent resistance in case of nucs combo another thing to keep very clear is that 1g alinia daily looks mostly ineffective since the maximum blood half-life of active level of alinia taken with food is 7 hours only so it is necessary to take alinia every 7-8 hours according to the total daily dose if 1.
Research shows that 61 out of every 1000 patients on 80mg of simvastatin develop muscle problems. I do believe the half life for Simvastatin is quite short, 5 hours or less. If you take 80mg, then 5hours later only 40mg will remain. Another 5 hours only 20mg. So after 24 hours there will only be around 2-3mg in your body which is top up time.
Hi, I'm a 51yr old male. I've been on simvastatin 40mg for a yr and a half. I've been working all my life in the construction game. Over this past 6 months or more i started having feet and knee problems and breathing heavily after walking up 3 flights of stairs. Soles and heels of feet are sore especially when getting out of bed in morning and when i'mon my knees i'm finding it hard to get up again.
Usually diet and exercise is the best first place to start, but with an LDL this high I would probably recommend starting a cholesterol lowering medication as well, such as a statin (e.g. atorvastatin, simvastatin). All medications have potential side effects, but the statins are relatively well tolerated by most people and your doctor should be watching for any dangerous side effects (which are rare).
keep in mind that it can help with interferon to boost response, used as monotherapy it never worked on members who tried it dose can be from 1,5g to 3,5g, the drugs has a short half life of about 4-5 hrs so yo should try to take the 500mg pills with meals every 5 hrs.
The plasma clearance of metronidazole may be decreased and the half-life prolonged in patients with impaired hepatic function. Therapy with metronidazole should be administered cautiously at reduced dosages in patients with severe liver disease.
After my bare metal stents were clogged and I almost got another heart attack, a DES was placed inside those two. Since then I have been having chest pains. I am currently on Plavix, Aspirin, Simvastatin, Lisinopril and Carvedilol/Coreg/. Stopped Lisinopril for a little bit and felt much better- unfortunately my blood pressure went a little up. Then my PCP substitute it for Losartan- have been taking this drug/25 mg/ for a week and feel extremely dizzy and nauseated.
On a side note, a study was done to measure the side effect rate in 19,000 people, half on a statin and half on a placebo. It was interesting to find that the rate of muscle and joint pain reported was identical by both groups. I personally have been on 40 mg of Simvastatin for years without any side effects, but everyone responds differently.
I thought it was a natural thing because I was grieving the life that I had lost and trying to live my new life with limitations that I am not use to. I cry easily at almost anything - especially when I discuus my stroke and what all hs happened over the last year. So my neurologist sent me to a neuro-psychologist. He explained to me that a stroke can cause depression due to the brain damage and that therapy is often needed to help with this aspect.
Of the two components of vytorin, simvastatin has clearly been shown to decrease the rate of death, myocardial infarction and stroke, in over 40,000 patients. It is probably the best studied statin, and I have no problems prescribing it. Ezetimibe has been shown to decrease LDL cholesterol, but there is no life saving data in the published literature. So it depends if you think that LDL lowering automatically improves mortality independent of the mechanism or not.
) My husband has had cirrhosis for at least 3 years, and he has simultaneously been taking a moderate dose of simvastatin (20mg/day) because of elevated cholesterol previously complicated by a near heart attack. He maintained that dose until just recently when treatment knocked his cholesterol down to unusually low levels (70s), so they cut his dose in half to keep in the the 100 ranges. There was an older post about statin use in hcv patients you might find interesting: http://www.
My fat intake increased a bit. Cholesterol back to 300. So I am avoiding fat again. Doctor suggested Simvastatin medicine but I did not buy it. I still think I can reduce it by following a strictly low fat diet. Well, I do not exercise except that I walk, or sometimes run a bit, to work. Walking time=15-30 min per day. * Should I take medicine and eat the food that I like (fat, cheese, meat etc.) or follow low fat diet (even if I find it not tasty) and avoid taking medicine?
red yeast rise (which contains naturally lovastatin, simvastatin and some other statins), simvastatin or other more powerful statins? is simvastatin the most potent since used already with interferon and studied in vitro with antivirals (most potent sim+etv 300:1) aslo what is the meaning of 300:1?150mg sim+0.5mg etv?
I take 20 mg of the generic, I think Lipator was more like 10 mg. For some reason my cardiologist's office contacted me and asked me to cut my simvastatin dose in half, cut the pills I had on hand. She said there is some concern about the statin and my calcium channel blocker. They wrote me a blood test prescription for a cholesterol check in 10 weeks, that is coming up in mid January. I do recall reading about some concern of simvastatin in doses as at 40 mg.
Both feet are numb and neuropathy has spread half way up his legs. He gets very dizzy, sweating, muscular weakness on walking even 50 yds. We have seen many specialists: Cardiologist: angiogram, blocked artery, been there long time, but other smaller arteries have taken over. Recent ECG "unremarkable". Vascular Surgeon: 6 yrs ago - angioplasty, stent put in right leg for pvd.. Recent consult: Circulation slightly impaired, but not cause of problem.
After my bare metal stents were clogged and I almost got another heart attack, a DES was placed inside those two. Since then I have been having chest pains. I am currently on Plavix, Aspirin, Simvastatin, Lisinopril and Carvedilol/Coreg/. Stopped Lisinopril for a little bit and felt much better- unfortunately my blood pressure went a little up. Then my PCP substitute it for Losartan- have been taking this drug/25 mg/ for a week and feel extremely dizzy and nauseated.
Note, I did not do a real strict diet with no fat. I still ate bacon on occasion (1 piece) and I always had half and half in my coffee. Mostly what I did was cut down on butter, the bacon, the amount of meat I ate, and other fats. I already was in the habit of cutting all fat off my meat (had done that for years). I also never ate junk food, fast food, or processed food. (I had never eaten that stuff. ) So, I surprised that pessimistic know it all doctor, lol.
The difference is dramatic, Lipitor has a half life of 14 hours compared to just 5 for Simvastatin meaning you can build up larger serum loads of Lipitor. As far as CoQ10 goes, it's a supplement so it has not undergone the kind of studies that medications go through. I falls under the "hey, it won't hurt you" category for me as there may be issues in which the body can absorb it.
was diagnosed almost 6 yrs back ..when had jaundice. My weight has increased a lot in last half a year .... it stands at 86-89 Kg...
I have a brother who had a severe blockage and double-bypass at age 50. I am also half Mexican which puts me in a higher risk category, from what I have read. The only health problem I had was depression and iron deficient anemia which was almost completely corrected through iron supplements and Wellbutrin. Then last week I had a heart attack after walking up a steep hill.
I asked her about oral treatments but she said I might have to take the tablets everyday for the rest of my life. I have not started treatment because I am still searching for the optimal option. For the past 3 weeks, I've been taking Chinese herbal medicine twice daily plus high dose of milk thistle to protect my liver. Last week (9 July 2011) my LFT results improved: ALT: 265 AST: 97 GGT: 67 I am booked to see another specialist in 4 weeks time. I know I should to start treatment asap.
I would just recommend coming off the flecaininde, trying another agent, such as sotalol or dofetilide and going on with your life. The simvastatin and the toprol are very good for CAD and for atrial fibrillaiton.
The most prominent cholesterol drugs are in the statin family, an array of powerful treatments that includes Mevacor (lovastatin), Lescol (fluvastatin), Pravachol (pravastatin), Zocor (simvastatin), Baycol (cervastatin), and Lipitor (atorvastatin). Many doctors say statin drugs have revolutionized patient care.
Left sided jaw pain would occur about 2-3 days every month to month and a half. About october, 2005- Found hard lump in left side of neck. Went to thyroid dr. to do a check and was normal. He reffered me to E.N.T. who dx acid reflux, TMJ disorder. He sent me to jaw specialist and had me take prevacid for a month. (although i had reflux while pregnant and took almost 2 bottles of tums, I did not feel any acid coming up at this time ever or had any problems to my knowledge) The e.n.t.
Hello. I have been dealing with an issue for a year and a half now, and I am trying to be certain of the cause. 2 years ago I had an episode in the middle of the night where I woke up with extreme pain and numbness in my left arm, radiating into my shoulder and left side of chest. I got up, relaxed, and gradually the pain/numbness subsided over a couple of days. I went to my doctor, got an EKG and stress test which I passed. An X-ray was done on my shoulder/neck and no bone spurs were found.
Cardiologist prescribed 75mg plavix, 325 mg aspirin, and 40mg simvastatin (zocor). Three days after the stent placement, I started with the chest pains again. Dr ordered 30mg isosorbide which gave me headaches everyday but no more chest pains. After 5 weeks my cardiologist said to cut them in half which I did and after 2 weeks I'm still getting the headaches and now mild chest pains again. Has anyone else had this problem?
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