simvastatin and liver enzymes

Warnings and Precautions Because simvastatin can affect the liver, it is used with caution in people who drink more than a moderate amount of alcohol or have a history of liver disease. Simvastatin is not recommended for people with liver disease or high liver enzymes before treatment begins. Possible Symptoms of Liver Problems Several symptoms can occur in someone who develops liver problems while taking simvastatin.

was on lipitor for 5 months and switched two weeks ago to simvastatin in hopes of less side effects. just got some blood work done and the liver enzymes are elevated about one and a half times normal. does anyone know if its normal to see a spike in liver enzymes after switching statins or does this mean my body is rejecting the new statin?

check also who is making the research on simvastatin, and that liver damage has been removed recently, at least here in italy

I rode it out and this went away. My enzymes (Liver or muscle) have not changed since starting it about 5 months ago.

pdf EMedTV has an article that explains some statins are associated with high liver enzymes. It says increases in liver enzymes occur in 1.7 percent of people taking Vytorin. This increase appears to be more prevalent in people who are taking higher doses. It goes on to explain other causes of high liver enzymes. The bottom line is the person best to determine this is one who is familiar with your medical history as well as your labs prior to starting the medication.

Patients taking statins will no longer need periodic monitoring of liver enzymes, since cases of serious liver injury are rare and unpredictable in individual patients." The bottom line is that there was NO connection found between statin use and memory loss, but it was seen in studies so it was added to the list of POSSIBLE side effects. One needs to see all the story to understand the meaning, not just the headlines.

AST & ALT are liver enzymes that increase when there is inflammation in the liver.

You are prescribed a low dose which is what I am on. Same drug also. It has been a year and my liver enzymes are 18 & 17. So far so good.

My understanding is that cautious doctors get a baseline value for your liver enzymes and re-test in a month or 6 weeks to see what impact the drug may be having. Often there will be mild elevations which don't appear to cause any liver impairment but it's best to stay on top of this stuff. Sometimes, if the enzymes become elevated, a different statin can be substituted which obtains the desired cholesterol lowering without as significant an elevation in liver enzymes.

4 [0027] These cases involve the administration of simvastatin to patients with known Hepatitis B and C, and other causes of liver cirrhosis, mainly alcoholic. All of these patients had normal alphafetoprotein levels and were given simvastatin on a daily basis since their first diagnosis of their liver disease. None of these patients showed an elevation of alphafetoprotein during an observation period.

They read up on all of her meds called the Dr. he stopped the simvastatin and she is much better now and cont to improve. My husband is on it and has no problems. As with most drugs, they affect people different.

Statins work in the liver and every commercial I have seen advises not to take if you have liver problems. Zetia works in the intestines. Was the Zetia working? If my memory serves me correctly, MikeS is taking statins and he had a TP. He is far more knowledgeable on the subject than I am and hopefully he will see this post and give his input. Zetia is part of a class of drugs called cholesterol absorption inhibitors.

I have been on 20 mg of simvastatin and 3000 mg niaspan now my ck levels have went from 60 to 295 i could hardly walk .will my levels come down if i lower dose. and reverse damage. i have 12 stents .the rest of my blood work is fine.

Simvastatin is contraindicated in pregnancy and liver disease, according to Wikipedia. I also know that Cresor 40mg is not recommended for Asians. I would like to know why you believe simvastatin and or statin in geneal have ant-hbv activities? Have you heard of cases where statins cause acute liver failure in chronic hbv patients?

Effect of the Magnitude of Lipid Lowerinf in Risk of Elevated Liver Enzymes, Rhabdomyolysis, and Cancer Insights from Large Randomized Statin Trials. J Am Coll Cardiology. 2007; 50(5):409-418.) Your doctor may tell you that as long as liver enzymes are three times the level of normal, that is, a three hundred percent elevation; it is alright to continue stain use. Most patients find this to be a rather scary approach to a medication.

-- Long-term use of cholesterol-lowering statins does not increase the risk of liver disease in patients with abnormal liver function, and can actually improve liver function, according to a new study that challenges widespread belief. The researchers also pointed out that this study is the first to show that statins provide a substantially greater cardiovascular benefit in patients with abnormal liver function than in those with normal liver function. The study, published in the Nov.

5 or 2g 2g can lower healthy bacteria in the stomach of some so probiotics are suggested on the 2g dose of alinia and on simvastatin it is better to check main blood tests, liver tests and creatinine for kidneys every 6 months

Tenofovir and Entecarvir only stop or reverse liver damage. Yes, it could help you get undetectable HBV DNA, but it also worsen your liver cells' infection? Does that even make sense? Because they inhibit HBV from growing, should they lower your virus load, then your liver should become less infected, and have time to repair itself? Alinia seems promising at dose 2g/day for HBeAg negative.

But in an in vitro study you have a constant exposure to the drug, which is impossible to achieve in vivo. And the cells used are not the same as regular hepatocytes in human liver, with many differences in gene expression and cellular physiology.

) For the past 20 years, I have avoided NSAIDs, acetaminophens, other pain relievers and muscle relaxants because of their adverse effects to liver and kidneys (personally more significant because my dad had kidney disease). Since cannabidiol inhibits the liver's production of cytochrome P450, I am wondering about switching from simvastatin to pravastatin. That would allow me to try CBD, which appears to have minimal side-effects.

As you know, I was on Vytorin for years and went back to Simvastatin about a year ago. I have tested twice since on Simvatstain alone and my numbers have actually dropped a little than during my Vytorin days. I'm only going by the Enhance trial that concudes; "The ENHANCE study enrolled 720 patients who were randomized to receive either Vytorin, or Zocor alone. As an endpoint, investigators looked at the growth of plaques on arterial walls using non-invasive ultrasound imaging.

Simvastatin and liver enzymes

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