Simvastatin and kidney disease
Common Questions and Answers about Simvastatin and kidney disease
vytorin
All of my cholesterol-related numbers are in a healthy range, and I have never experienced any serious side effects (e.g., muscle weakness, kidney and liver impairment, etc.). I have, however, had trouble sleeping for the past several years (perhaps caused by simvastatin, perhaps not). More importantly, I have been experiencing back pain for the past few months and would like to try CBD. I am down to sleep a few hours a night.
As you know, I was on Vytorin for years and went back to Simvastatin about a year ago. I have tested twice since on Simvatstain alone and my numbers have actually dropped a little than during my Vytorin days.
I'm only going by the Enhance trial that concudes;
"The ENHANCE study enrolled 720 patients who were randomized to receive either Vytorin, or Zocor alone. As an endpoint, investigators looked at the growth of plaques on arterial walls using non-invasive ultrasound imaging.
I am currently 30 years old and when i was 28, I had a kidney transplant on April 22, 2008. Since that time I was able to start running again and completed the 2010 Houston Marathon in a time of 2:41:20 - 6:09 per mile! Following the race my Dr. told me that my total cholesterol was 303!!! So they instantly prescribed me 20mg of Simvastatin. With in a matter of 7-10 days I was nearly unable to run my legs became so heavy. Lead Legs!
4
[0027] These cases involve the administration of simvastatin to patients with known Hepatitis B and C, and other causes of liver cirrhosis, mainly alcoholic. All of these patients had normal alphafetoprotein levels and were given simvastatin on a daily basis since their first diagnosis of their liver disease. None of these patients showed an elevation of alphafetoprotein during an observation period.
“If you are unaware that a patient is on simvastatin and you give either boceprevir or telaprevir, the simvastatin level in the blood can go high and patients can develop muscle breakdown,” said Dr. Jensen.
http://www.idse.net//ViewArticle.aspx?
In any case, with the simvastatin my total is normally under 150. I now suffer from heart disease and am senior aged so I have to keep my cholesterol low.
I have no blockages and have low/normal blood pressure, but I also take medications for atrial fibrillation which lower my blood pressure.
Warnings and Precautions
Because simvastatin can affect the liver, it is used with caution in people who drink more than a moderate amount of alcohol or have a history of liver disease.
Simvastatin is not recommended for people with liver disease or high liver enzymes before treatment begins.
Possible Symptoms of Liver Problems
Several symptoms can occur in someone who develops liver problems while taking simvastatin.
Advicor (lovastatin/niacin extended-release), Simcor (simvastatin/niacin extended-release), and Vytorin (simvastatin/ezetimibe).
1) At my age 69.5 and a daily dosage of 4 ibuprofen OR 3 naproxen, do I have to worry about kidney disease resulting from a "total lifetime dose" of ibuprofen/naproxen ??
2) At recommended dosage and over a lifetime, does acetaminaphen have less potential to harm me than either ibuprofen or napproxen?
3) Is there a "total lifetime dose" concern for acetaminaphen?
Thank you for answering questions in this forum !!
I have also been onTerbi nafine since January
In the last month or so I have encountered pins and needles in my arms and legs - worse in the middle of the night; an ache/twitch/Tnderness in my neck - mainly on the left side; digestion problems worse than usual (lot of wind and diarrhoea); great fatigue at times, and a strong feeling of unwellness at times. I also have various tender points on my ribs. Finally - my breasts have become very tender in recent weeks.
Simvastatin is contraindicated in pregnancy and liver disease, according to Wikipedia. I also know that Cresor 40mg is not recommended for Asians. I would like to know why you believe simvastatin and or statin in geneal have ant-hbv activities? Have you heard of cases where statins cause acute liver failure in chronic hbv patients?
I am taking 40mg nexium once daily and have recently been Rx'd simvastatin (10mg). It's a low dose, but there appears to be a potential moderate interaction, possibly myopathy and shortness of breath. I called the pharmacist and he said that unless I was taking a higher simvastatin dose (>50mg), I shouldn't have a problem.
I'm on Simvastatin (40mg) which have some nasty side effects, like cramps and muscle spasms. Can you reommend an alternative?
Beta blockers like metoprolol and ACE inhibitors like benazepril have been been shown to be of value in patients with congestive heart failure as well as for hypertension. Simvastatin is of value for patients with both diabetes and heart disease. Talk to your doctor and changes can be made to minimize the side effects.
I quit taking the simvastatin last tuesday, and by friday I looked perfectly normal with no steroid cream......
Thanks again for all the help!
I'm 62, and after being diagnosed with "high cholesterol about 12 years ago, I've been on simvastatin (20mg). This has always been an entirely "preventative" measure. No heart disease, I'm skinny (120lbs), don't smoke, hardly drink. Get exercize. I'd love to stop taking the statin given the data on possible muscle damage and cognitive issues.
Without taking the statin my recent numbers are HDL 63, LDL 152, overall 235, with a ratio of 3.7.
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