Simvastatin and gemfibrozil interaction

Common Questions and Answers about Simvastatin and gemfibrozil interaction

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527657 tn?1214051850 Concurrent use of gemfibrozil and statin drugs such as simvastatin should be avoided. Please discuss the possible risks vs. benefits of taking these 2 drugs with your physician.
Avatar n tn i have been taking tri-cor and simvastatin (40mg) for several years. Over the last 8 months i stopped taking the tri-cor because insurance no longer covered it and I decreased my simvastatin to 20mg. At the same time in increased my fiber significantly (metemucil and high fiber cereal daily) and began taking one 1000mg of fish oil each day. Lost a few pounds as well, I'm 41, 5'10" and 173lbs non-smoker.
7569019 tn?1460135460 now down to 10) 4 days of major charlie horses Dr said stop taking Gemfibrozil.. and to help with the swelling I was put on lasix furosemide 20 mg and pot chloride 20 meg.. I am drinking more water but not peeing anymore than normal..dizzy tho.and sometimes short of breath, especially when walking or talking..how much water should I be drinking, an the muscle cramps and weakness of my legs will they get better? This kills me.. the pain last for hours after a cramp.
Avatar f tn “If you are unaware that a patient is on simvastatin and you give either boceprevir or telaprevir, the simvastatin level in the blood can go high and patients can develop muscle breakdown,” said Dr. Jensen. http://www.idse.net//ViewArticle.aspx?
Avatar n tn There is only one interaction that would be of any concern. Treatment with both simvastatin and niacin may result in muscle pain or tenderness or muscle weakness. Using simvastatin together with niacin is usually not recommended, but may be required in some cases. If you are using both medicines together, your doctor may change the dose or how often you use one or both of the medicines. It is important to tell your doctor and pharmacist about all other medicines that you are using.
Avatar m tn I take some medications for cholesterol and migraine prevention (Gemfibrozil, Simvastatin, and Atenolol). Some of the medications list chills as a possible side effect, but this recurring theme of night-time intense cold followed by sweats is more specifically what I'd like to find the cause of. It may only happen once every couple of months for me, yet I'd sure like to figure out what is causing it. Normally, I prefer a cooler room to a warmer one.
Avatar n tn I am taking 40mg nexium once daily and have recently been Rx'd simvastatin (10mg). It's a low dose, but there appears to be a potential moderate interaction, possibly myopathy and shortness of breath. I called the pharmacist and he said that unless I was taking a higher simvastatin dose (>50mg), I shouldn't have a problem.
Avatar m tn I like to drink grapefruit juice but hear that it can interfere with some prescription medications. Is that true? Answers from Katherine Zeratsky, R.D., L.D. Yes. Grapefruit and certain other citrus fruits and products can interfere with several kinds of prescription medications. Don't take these interactions lightly. Some can cause potentially dangerous health problems.
Avatar n tn Also, increase your level of exercise and avoid all processed foods, sugar and alcohol.
501096 tn?1320874932 We have been trying again since May, but I recently discovered that Gemfibrozil (and similar meds) may cause male infertility or reduced fertility. Is this accurate? If so, how long would it take for the medicine to clear his system and his fertility to return? We have 3 healthy kids and have had 2 m/c (2003 & 2008). Thanks for your assistance.
Avatar f tn Yes, I understand there is an interaction between victrelis and grapefruit and I learned it on this board too. Then I looked for the confirmatin on that and found it in Victrelis' labeling. I don't believe either Victrelis or Incevik have been used to treat HIV. They were just approved in May, 2011, for the treatment of Hepatitis C. They are in a class of new drugs that target the specific virus and there are HIV drugs that do the same - but not the same drugs.
Avatar m tn Meds are as follows;MULTAQ-WARFARIN-GEMFIBROZIL-SIMVASTATIN-METOPROLOL-ASPIRIN.Any advice greatly appreciated!
Avatar n tn In most cases, the clinical consequence of the pharmacokinetic interaction has not been evaluated. However, for midazolam and triazolam, as well as for buspirone, impairment of CNS function was observed, and for the calcium channel blocker felodipine greater blood pressure lowering has been observed. In contrast to the increased levels of the other medications, the grapefruit juice interaction observed with theophylline and itraconazole was reduced plasma concentrations.
1310757 tn?1273645428 Different doctors have just commented on how high it was without telling me answers and I never questioned. With Gemfibrozil it is hovering in the high 200's.
600301 tn?1219689156 Exercise, Niacin, Fibrates ( such as gemfibrozil) and some statins can all raise HDL. Alcohol consumption in moderation can also do this. Whereas there is a strong link between low HDL and risk for cardiac death and heart attacks, there is very little evidence that increasing it with drugs ( appart from gemfibrozil and Niacin) actually improves patient's mortality.
315318 tn?1353251800 I've been taking simvastatin and Tricor for years without issue. Are you sure you were on a fenofibrate or a fibrate? There are some issues when using a fibrate along with a statin but the side effect incidence when combining a fenofibrate and statin are extremely low. Being a diabetic is also an issue with the use of a fenofibrate as the combined therapy does not appear to be any more effective than a statin alone.
Avatar n tn I quit taking the simvastatin last tuesday, and by friday I looked perfectly normal with no steroid cream...... Thanks again for all the help!
Avatar f tn 5 mg/dl and mean LDL cholesterol 111 mg/dl, were randomized to gemfibrozil 1200 mg/d or placebo and were followed up for 5 years. In the VA-HIT study Gemfibrozil resulted in 6 % higher value of HDL cholesterol, 4 % lower for total cholesterol and 31% lower for the triglycerides compared with placebo. There were 134 confirmed strokes, 90%of which were ischemic. 76 occurred in the placebo group and 58 in the gemfibrozil group, for a relative risk reduction of 31%.
Avatar m tn I use simvastatin to lower the cholesterol and lisinopril to lower the bp. The lisinopril works w/o the simvastatin and v.v.
Avatar m tn Amlodipine is a calcium channel blocker while lisnopril is an angiotensin converting enzyme(ACE) inhibitor. Both groups of drugs and simvastatin are unlikely to cause erectile dysfunction. However yes, all three of them can cause swelling of ankles. Talk to your doctor. You can change your medications. Among antihypertensives you need to avoid thiazides , beta blockers and alpha blockers. High blood pressure and reduced blood supply to penis can also cause erectile dysfunction.
Avatar n tn I have been on 20 mg of simvastatin and 3000 mg niaspan now my ck levels have went from 60 to 295 i could hardly walk .will my levels come down if i lower dose. and reverse damage. i have 12 stents .the rest of my blood work is fine.
1175033 tn?1492201228 I started taking Valium recently and noticed that the bottle warned not to consume grapefruit of the juice at all while taking this medication. This was a issue for me because I drink hansen's natural cane sugar soda with real grapefruit extract and I had to give that up, but I really didn't want to so I read up on what it will do. One article I came across said it would increase the potency of certain meds by 400% http://www.mayoclinic.
Avatar n tn On a recent blood test my potassium level was above normal. I stopped taking simvastatin. After 3 months I took another blood test and now my cholesterol level has risen to 6.5. What shall I do. I am seeing my Doctor next week.
Avatar n tn s group at Harvard in 1966, it was clearly established that Omega 3 fatty acids and Vitamin C, combined with a low carbohydrate diet, can dramatically reduce your triglyceride levels. Omega 3 fatty acids can help with cholesterol as well.
Avatar f tn Patients were put on a cholesterol-lowering diet and given one of the medications. After 18 weeks, patients given simvastatin had significantly lower total cholesterol, lower LDL, lower triglycerides, and higher HDL cholesterol levels than those who took pravastatin. The study found that the patients on simvastatin achieved the target LDL level of less than 130, more than those on pravastatin (65 percent on simvastatin versus 35 percent on pravastatin).