simvastatin and erythromycin interaction

“If you are unaware that a patient is on simvastatin and you give either boceprevir or telaprevir, the simvastatin level in the blood can go high and patients can develop muscle breakdown,” said Dr. Jensen. http://www.idse.net//ViewArticle.aspx?

I do believe that my digestion has been sped up, and I believe the Erythromycin sped up the Percocet in my body and essentially made it as if I overdosed. I tried talking to a pharmacist about this, but she said the Percocet would have stayed in my body for a longer period of time, not run through it faster. I don't believe this is the case, though, because after an hour and a half all of my pain was back again. My heart calmed, I stopped shaking, and I was in pain.

(ONE SLIGHTLY ENLARGED LYMPH NODE, BUT NO PROBLEM.) HE PRESCRIBED METHYLPREDNISOLONE AND ERYTHROMYCIN. I NOTICED ABOUT THE SECOND DAY THAT MY HEARTBEAT WAS FASTER, I WAS HAVING TROUBLE SLEEPING AND I HAVE HAD VAGUE, DULL CHEST PAIN. I CALLED MY REGULAR DR.'S NURSE THIS MORNING ABOUT TEST RESULTS, AND TOLD HER ABOUT THE EXTRA HEARTBEATS AND CHEST PAIN. SHE TALKED TO THE DR., CALLED ME BACK AND TOLD ME TO STOP TAKING THE STEROIDS.

There is only one interaction that would be of any concern. Treatment with both simvastatin and niacin may result in muscle pain or tenderness or muscle weakness. Using simvastatin together with niacin is usually not recommended, but may be required in some cases. If you are using both medicines together, your doctor may change the dose or how often you use one or both of the medicines. It is important to tell your doctor and pharmacist about all other medicines that you are using.

I am taking 40mg nexium once daily and have recently been Rx'd simvastatin (10mg). It's a low dose, but there appears to be a potential moderate interaction, possibly myopathy and shortness of breath. I called the pharmacist and he said that unless I was taking a higher simvastatin dose (>50mg), I shouldn't have a problem.

Advicor (lovastatin/niacin extended-release), Simcor (simvastatin/niacin extended-release), and Vytorin (simvastatin/ezetimibe).

Concurrent use of gemfibrozil and statin drugs such as simvastatin should be avoided. Please discuss the possible risks vs. benefits of taking these 2 drugs with your physician.

I like to drink grapefruit juice but hear that it can interfere with some prescription medications. Is that true? Answers from Katherine Zeratsky, R.D., L.D. Yes. Grapefruit and certain other citrus fruits and products can interfere with several kinds of prescription medications. Don't take these interactions lightly. Some can cause potentially dangerous health problems.

I just remember reading that there was an interaction between opiates and erythromycin that affected absorption of one (or the other). It was when I had to undergo a round of antibiotics myself, a few months back.I was told to watch for extra dowsiness or changes in how I felt from my meds. It ended up not affecting me and I was able to take the full course of antibiotics without any probs. But we are all different critters and Luv2, you are new to Fentanyl.

Yes, I understand there is an interaction between victrelis and grapefruit and I learned it on this board too. Then I looked for the confirmatin on that and found it in Victrelis' labeling. I don't believe either Victrelis or Incevik have been used to treat HIV. They were just approved in May, 2011, for the treatment of Hepatitis C. They are in a class of new drugs that target the specific virus and there are HIV drugs that do the same - but not the same drugs.

I checked the drug interactions for Sovaldi and Olysio on their Patient Information sheets. On the Olysio PI it says to avoid taking Erythromycin and derivatives. Azithromycin, which is what I normally take during dental work, is made from Erithromycicn, according to Wikipedia, so I probably shouldn't take it. But I've have trouble (serious gastrointestinal problems) with the alternative antibiotic, Amixicillin. Does anyone here know about this stuff.

In most cases, the clinical consequence of the pharmacokinetic interaction has not been evaluated. However, for midazolam and triazolam, as well as for buspirone, impairment of CNS function was observed, and for the calcium channel blocker felodipine greater blood pressure lowering has been observed. In contrast to the increased levels of the other medications, the grapefruit juice interaction observed with theophylline and itraconazole was reduced plasma concentrations.

It is likely the patient had acute colchicine toxicity brought on by the addition of erythromycin and superimposed on chronic colchicine intoxication secondary to renal and hepatic impairment. The patient improved with supportive therapy and intensive hemodialysis and was discharged on day 70 of hospitalization. Another report describes two fatal cases of agranulocytosis due to presumed interaction between colchicine and clarithromycin, a potent CYP450 3A4 inhibitor.

The Incivek prescribing informations lists clarithromycin, erythromycin and telithromycin as antibacterials that can cause drug interaction. "Concentrations of both telaprevir and the antibacterial may be increased during co-administration. Caution is warranted and clinical monitoring is recommended when co-administered with telaprevir. QT interval prolongation and Torsade de Pointes have been reported with clarithromycin and erythromycin.

You are lucky fi you can take antibiotics at all. Antibiotics (almost of them) close my throat. Antibiotic treatment for something as simple as strep throat could kill me. I've had several close calls. I'd love to be able to just take an antibiotic when I have something bacterial, or when I need surgery. Life is a lot more risky for me.

I've been taking simvastatin and Tricor for years without issue. Are you sure you were on a fenofibrate or a fibrate? There are some issues when using a fibrate along with a statin but the side effect incidence when combining a fenofibrate and statin are extremely low. Being a diabetic is also an issue with the use of a fenofibrate as the combined therapy does not appear to be any more effective than a statin alone.

Karch says when the system is overloaded, the grapefruit juice can “swamp” the system, keeping the liver busy and blocking it from breaking down drugs and other substances. Drugs that use the same pathway and interact with grapefruit juice target some of the most common health problems doctors see today. The list consists of more than 50 medications, including some drugs used to treat high cholesterol, depression, high blood pressure, cancer, depression, pain, impotence, and allergies.

I quit taking the simvastatin last tuesday, and by friday I looked perfectly normal with no steroid cream...... Thanks again for all the help!

i have been taking tri-cor and simvastatin (40mg) for several years. Over the last 8 months i stopped taking the tri-cor because insurance no longer covered it and I decreased my simvastatin to 20mg. At the same time in increased my fiber significantly (metemucil and high fiber cereal daily) and began taking one 1000mg of fish oil each day. Lost a few pounds as well, I'm 41, 5'10" and 173lbs non-smoker.

I use simvastatin to lower the cholesterol and lisinopril to lower the bp. The lisinopril works w/o the simvastatin and v.v.

Amlodipine is a calcium channel blocker while lisnopril is an angiotensin converting enzyme(ACE) inhibitor. Both groups of drugs and simvastatin are unlikely to cause erectile dysfunction. However yes, all three of them can cause swelling of ankles. Talk to your doctor. You can change your medications. Among antihypertensives you need to avoid thiazides , beta blockers and alpha blockers. High blood pressure and reduced blood supply to penis can also cause erectile dysfunction.

I have been on 20 mg of simvastatin and 3000 mg niaspan now my ck levels have went from 60 to 295 i could hardly walk .will my levels come down if i lower dose. and reverse damage. i have 12 stents .the rest of my blood work is fine.

Simvastatin and erythromycin interaction

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