Simvastatin and cpk
Common Questions and Answers about Simvastatin and cpk
zocor
I was on simvastatin also and my cpk was high and getting higher and they took me off immediatly. as I understand it all statins have the potential to cause cpk to rise. you may want to stop taking it. check w/ your Dr.
Last month my doctor upped by dose from 20mg to 40mg. I told him I was having aches and pains, so he took a cpk test for cardiac enzymes. It was normal, so he told me to stay on the 40mg. In fact he said he has stronger cholesterol medicine if he needs to use them.
No dr in the past has ever increased the dose past 20mg.
Now I have aching in the top of both of my feet, my arm, and my back.
I have had pain before in my body, but this is worse.
I am thinking about seeing a different dr.
If this is raised then there is muscle injury and the drugs should b stopped. If CPK is normal, then the dose and exercise adjustment should help. Fat-soluble statins like Lipitor and Zocor cause more damage than water soluble statins like Pravachol and Crestor. Hence the latter should be tried at lower dose. Possibility of hypothyroidism and diabetes should be ruled out as the presence of either disease can complicate the muscle pain.
I was put on metoprolol200 mg per day, amlodipine 10 mg, and since my high sensitivity c-reactive protein was 8.9, I was put on simvastatin 5mg. The medicine was controlling my blood pressure over the last couple of months but now it is not. I consistently run in the 150/95 range. My resting heart rate stays around 90. Is it normal for meds to just stop working, literally overnight? Should I be concerned about my risk of heart attack or stroke? Any advice is appreciated.
Even though there is no blood test for fibromyalgia, blood tests are important to exclude other medical conditions. Therefore, thyroid hormone and calcium blood levels are obtained to exclude hypercalcemia, hyperparathyroidism, and hypothyroidism. The blood alkaline phosphatase (a bone enzyme) level is often raised in patients with Paget's disease of the bone. The CPK (a muscle enzyme) level is often elevated in patients with polymyositis, a disease with diffuse muscle inflammation.
“If you are unaware that a patient is on simvastatin and you give either boceprevir or telaprevir, the simvastatin level in the blood can go high and patients can develop muscle breakdown,” said Dr. Jensen.
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CPK is found in skeletal muscle and myocardium (heart muscle). Lipitor can cause various levels of elevation and associated symptoms like muscle aches, weakness and atrophy. The elevated CPK may be of no consequence or it may cause serious problems depending upon the degree of elevation and the symptoms. A severely elevated CPK can cause liver damage. I would consult with your physician to determine if this is a new finding.
I quit taking the simvastatin last tuesday, and by friday I looked perfectly normal with no steroid cream......
Thanks again for all the help!
I use simvastatin to lower the cholesterol and lisinopril to lower the bp. The lisinopril works w/o the simvastatin and v.v.
CPK-1 or CPK-BB is elevated in brain or lung pathology. CPK-MB or CPK-2 in heart pathology and CPK-3 or CPK-MM is elevated if skeletal muscles are the cause.
I think you should discuss these possibilities with your doctor. It is difficult to comment beyond this without examining. A comprehensive investigation is required keeping all the points in mind. Take care!
Amlodipine is a calcium channel blocker while lisnopril is an angiotensin converting enzyme(ACE) inhibitor. Both groups of drugs and simvastatin are unlikely to cause erectile dysfunction. However yes, all three of them can cause swelling of ankles. Talk to your doctor. You can change your medications. Among antihypertensives you need to avoid thiazides , beta blockers and alpha blockers.
High blood pressure and reduced blood supply to penis can also cause erectile dysfunction.
Certain medications, trauma, inflammation (myositis), alcohol, genetic problems with the muscle, and viral infections can all cause CPK elevation. CPK is an enzyme that is found within muscle cells. When the muscle cells are damaged for any reason, the CPK is released into the blood resulting to increased levels in the test. I would recommend that you continue monitoring your CPK levels and have regular follow-up with your doctor. Take care and regards.
Other symptoms are anxiety, cough, dizziness, palpitations, shortness of breath etc. your doctor would like to check the cardiac enzymes like troponin and CPK, CPK MB. Continuous oxygen and morphine, anti thrombolytic therapy, anti arrhythmic, etc are required. You need to get an MRI cervical spine to check for any prolapsed disc or degeneration. Hope this helps. Take care.
I have gone off them from time to time and, after my CPK levels dropped, gone back on them. Recently I went off the statins because my CPK level was around 430. After being off of the statins for about two months, my CPK level actually went up to 640. I was tested again last week (after another two weeks) and my CPK was 730. My doctor just ordered an Aldolase test to see if that was normal.
I have frequent cramping and muscle tightness in my legs.
CPK-1 found mostly in the brain and lungs and higher than normal level is associated with the pathology of brain and lungs. Similarly, higher CPK-2 level is associated with heart pathology. Additionally, CPK-3 is associated with muscle inflammation or injury. Therefore, i would recommend you consult with your doctor for a better insight of the situation to know which CPK is elevated in your case. Hope this helps.
Hi
Welcome to the forum!
“When the total CPK level is very high, it usually means there has been injury or stress to the heart, the brain, or muscle tissue. For example, when a muscle is damaged, CPK leaks into the bloodstream. Determining which specific form of CPK is high helps doctor's determine which tissue has been damaged.
They called me yesterday and said the CPK was elevated and that he thought it was the reason for my increased problem with the inflammation. So, he wants me to have it drawn again next week and if it's still elevated he wants me to have it worked up further.
I googled CPK and there's like SO MANY different things that can cause it that it's really hard to be able to know. I had been working out at the gym more, since last Feb.
Went to the doctor who diagnosed me with muscular dystrophy after looking at my blood test results- My CPK levels were at about 1300. I went for an EMG test in Jordan and they found nothing wrong with my muscular activity. My family were not convinced so they sent me to Canada for another EMG test- which also showed that there is absolutely nothing wrong with me!
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