Side effects of ribavirin and interferon

Common Questions and Answers about Side effects of ribavirin and interferon

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Greetings, wishing all a return to health and happiness. My question and concerns pertain to the chronic problems I have encountered since my therapy. I did the year on Interferon and ribavirin, responded then came out of remission with a vengeance. The depression was unbearable, also the flu like symptoms. When I ended the therapy I had acquired fibromyalgia, hoshimoto's thyroiditis, increased viral count, GI problems, and a new personality!...
There seems to have little or no research studies regarding Post Pegylated Interferon and Ribavirin related side effects and so I put this question out to patients who have done this treatment.
Yes, people can and do successfully complete antiviral therapy with the current standard of care which is interferon and ribavirin. The odds of reaching a sustained virological response or cure depends on genotype, degree of liver damage, age, how long you've had the virus just to name a few. Here is a good website containing good basic information regarding hepc and treatment: http://www.janis7hepc.
All of my other treatments (except one clinical trial I was in that didn't include Ribavirin)- I was on the Interferon and Ribavirin. I have more side effects from antidepressants than I do from being depressed, so for me, I do better w/o them. I am a firm believer with exercise. It helps alot of things including depression. Exercise doesn't have to be the same cookie cutter work-out routine for every person. Some people may prefer to swim. Others may enjoy walking outside.
BTW: There never was a "98% cure rate for peg-interferon and ribavirin treatment for hepatitis C and there still isn't. If there was, there would be very few people chronically infected with hepatitis C instead of millions. As far as your husband having cluster headaches. Just because a person has hepatitis C doesn't mean they aren't going to have other diseases and conditions too.
What they don't tell you is that while the sx of interferon tend to leave quickly...a mo or so after treatment ends, the sx of ribavirin stay with you for at least six mos., although substantially decreased, and it may cause michtochondrial changes in your blood cells.....
Two extra strenth tylenol actually work pretty well and I will be able to tolerate this for a year if I have to. I'm hoping it will taper off. Do anyone of you have these side effects to ribavirin? Thanks.
Stuff I just didn't do before treatment and haven't done since. Often, as the Peg takes effect -- and/or the anemic effects of the ribavirin -- the riba edginess gets muted somewhat but at least for me, was always there under the covers. I remember having actual tears in my eyes after watching some corny tv show or even a commercial. It is a real emotion intensifier. Many here have taken ADs or sedatives and that's helped.
Side effects from sofosbuvir and ribavirin treatment are listed in the top line results of the clinical trials. "In FISSION (Genotype 2/3 treatment-naïve), just 1% of patients receiving 12 weeks of sofosbuvir plus ribavirin discontinued therapy. However, a higher rate — 11% — of patients who received 24 weeks of peginterferon plus ribavirin stopped treatment.
In the beginning of treatment I was sick from a bad liver and the effects of the virus AND sick from the combo. Soon though, I noticed that I felt better and could do a number of things I couldnt do before. This coincided with the virus clearing. Yea the tx was definitely tough but I was suddenly aware that my body was getting better. These two things actually balanced out and helped me to stay on the tx.
Its been 8 days since the last dose of pegasys and 2 days since the last dose of ribavirin but the nausea and other problems are still there.My question is how much long does it take for nausea to go away after the treatment is stopped?Are there any other considerations that we need to take? An early response would be highly appreciated Thanks and God bless All.
I am going to start on Interferon Maintenance and would like to know if the side effects are similar to the treatment? I completed interferon/ribaviron in 2004 but did not have a SVR. I just finished a week of Infergen/Ribavirin and quit the treatment. It was just too intolerable. Anyone need Infergen?
Seems like it hasn't bothered the guys on this forum but on another HCV forum the guys there have made sort of a joke of the situation that many of them have experienced while on TX and gave this particular side effect a name: Urdixaflopin.
I am a geno 2b female 58 yrs old stage 2 grade 3. I was diagnosed in 2000. I found this website late last year and these good people got me out of my fear paralysis and down the road to treatment. I am starting my 7th week of the 24 wks recommended for our genotype. (I agree--do all 24 weeks...don't take a chance.) I am very health conscious too, active, etc. Also prone to depression and have thyroid problems all over my family (both sisters, one daughter, one niece so far). SO.
Like Susan400, my doctor wouldn't allow me to take the Sovaldi/ Olysio combo because of my partial and poor response and side effects I experienced with Victrelis (Boceprovir) and RIBA/Interferon. This go around I've had some tough days, but really am functioning pretty normal except for a couple days after my shot. I had quite a drop in my WBC as well, but it has leveled off since week 6.
, and I'm still having a lot of pain. Lot's of joint and muscle pain and lot's of fatigue. This in turn, makes me get depressed. I want to be able to get out and live w/o having to spend 4-5 days after it trying to function again. People don't understand do they? I know it's frustrating. Maybe you could see if there are any hepatologists in your area, who would be more knowledgeable about the post treatment issue, I don't know...
The interferon you are talking about is called Infergen, Consensus Interferon. There haVe been plenty of people in here over the last years that have done this form of treatment however most people just do the weekly interferon and riba combo. Google up Infergen and you'll have it. Unfortunately most of the sides are the same as with weekly - but they can be more hard core.
The doctor has suggested and is highly recommending peg intron and interferon therapy... I have mixed feeling after looking up the side effects and reading some of the stuff on Lloyd website, I am questioning my own beliefs.I am scared, and uncertain of what to do. oh and i'm type 1.
Are you having side effects from the Interferon? I finished treatment nearly 4 years ago and happy to say the Hep C has been in control but have terrible joint pain and a host of other problems . Was just diagnosed with fibromyalgia (another name). I don't want to sound like a whiner. I just hope to find someone who is having similiar experiences and if there are any studies being done. I've tried talking with my doctors and they evade.
//www.medhelp.org/posts/Hepatitis-C/Long-term-side-effects-of-interferon/show/866107 http://www.medhelp.org/health_pages/Hepatitis/Members-Comment-on-Side-Effects-of-the-Treatment-Drugs-During--After-Treatment-/show/530?
5 VL Copies apx BMI Body Mass Index WHR Waist to Hip Ratio Drug Acronyms IFN Interferon (Alpha 2a / Alpha 2b) NPIA Non-Pegylated Interferon Alpha PegIFN Pegylated Interferon (Alpha 2a / Alpha 2b) CIFN Consensus Interferon (Infergen/alphacon) RBV Ribavirin RVN Ribavirin Riba Ribavirin WBR Weight Based Ribavirin WBD Weight Based Dose FDR Fixed Dose Ribavirin LDR Low Dose Ribavirin (Same as FDR) EPO Erythropoietin Epoetin alfa (Epogen/Procrit), Darbepoetin alfa (Aranesp) Neup Neupo
a high prevalence of genotype 1, problems in achieving full doses of IFN and RBV because of side effects, and a risk of complications related to impaired liver function. As mentioned above, the objective is not to reduce the viral load at transplantation because this has not been shown to decrease the rate and severity of recurrence, in contrast to HBV cirrhotic patients.
Incivek is a tablet that is taken three a day, in my husband's case 375 mg, 2 tablets 3x/day. Both of these drugs, VIC and INC are protease inhibitors that, when combined with Interferon and Ribavirin, significantly improve the chances of getting rid of Hepatitis C. Hope this helps.
Also, many people here will be glad to share their experience with you. I have severe emotional side effects that include insomnia, irratibility and some bouts of depression that come and go. I can deal with it though and so can most people.
I guess as everyone else, I am really in doubt about the tx, since I am really feeling good at 41 and I was told by some patients who that once you do a tx, that is it, if you do not kick the virus out, there is no more chance, besides now having all kinds of side effects from the 48 weeks of the worst! Interferon. I really do not know about it, it is just what I hear. Thanks again and good luck, brazeagle Look at this site and video!!! SCARY about interferon! www.lloydwright.
It seemed to work and helped me sleep as well. At one point i was taking 5-6 benadryls and 2000 mg of tylenol to help with the side effects. I had to take tylenol in the morning to get out of bed, when i was able to get out of bed. I became extremely breathless as i was fairly active, enjoyed exercise, going to the gym, cycling, but had to stop, because i felt faint most of the time. Just going to work was challenging enough for me. I also take anxiety medication to help me sleep.
Hi Can anyone tell me what the long term side effects of interferon /ribavarin are? Thank you very much. My hubby just finished weeks and I am wondering which sides will be here to stay and which ones I can expect to leave.
i live in france and dont speak the language too well to even try to discuss it with the medical fraternity: i now see what i presently experience is the same for others i dont fel so confused like its my imagination and i should feel better than i do: muscle pain, joint pain, depression: it helps to know this is how it is for others: i chose to do treatment after few years of avoiding aware of the "results": but i wanted to live: now i have cleared the virus, one wants to be a
My experience (48 weeks of treatment) was that side effects varied, some would come and go, others were with me throughout. The worst for me was the hemolytic anemia. I had to have a transfusion at week 6 and took the rescue drug, Procrit, for 40 weeks. The anemia causes exhaustion, dizzyness and extreme shortness of breath. The good news is that the anemia indicates that your ribavarin dose is not too low.
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