I believe that the most important factor is the too-large dose of
sertraline. Cutting back to 100mg has not seemed to
increase depression or anxiety. I figure, the lower the dose of anything, the better. It is difficult to find much certainty from any information source about Zoloft and twitching, but it has not gone without being noted here and there. Check with your medical professional -- of course -- before changing anything in any way. I am only telling you what I have experienced.