Atypical antipsychotics can have a lot of side effects. If you think your memory problems are from the seroquel, talk to your doctor about changing your meds around. If they're for schizophrenia or schizoaffective disorder, you'll need to stay on some sort of antipsychotic, but different ones have different side effect profiles for different people. If it's for bipolar or as an add on for depression, you can switch drug classes entirely, which might work better for you.