I found Lamictal to be a godsend to even out my moods, and I'm not
bi-polar - but there are side effects, and not everyone can take it because in a small percentage of people it can cause Stevens Johnson syndrome. I tried 25 mg Seroquel
during my periods, and it evened me out, but was too sedating. You and your doctor will find the right combo with some experimenting. So don't let that keep you from trying Topomax - worst thing that can happen is you don't like it and quit.