Some may remain bound to tissues, so it can take days to months to fully get rid of a drug, but the levels are likely to be too low to notice, and
with such a short half life and
only moderate lipid solubility, I don't think Seroquel
will hang around for too long. Some people think that this effect can cause drug interactions, but I don't know how much evidence there is for this. Receptors will adapt over time, but I don't know how fast the process is.