Risk of convulsions may also increase in patients with epilepsy, those with a history of seizures, or
in patients with a recognized risk for
seizure (such as head trauma, metabolic disorders,
alcohol and drug withdrawal, CNS infections). In tramadol overdose, naloxone administration may increase the risk of seizure.
Suicide Risk
•Do not prescribe ULTRAM ER for patients who are suicidal or addiction-prone.