Causes for unequal pupils are usually eyedrops, bleeding inside the skull, migraine headache,
seizure, excess eye pressure in glaucoma, Horner’s syndrome etc. Eye twitching is an involuntary eyelid contraction affecting the lower lid, caused by stress, high caffeine intake, fatigue or squinting. To relieve this try warm compressed application, gentle massaging of eyelid with fingers, over the counter antihistamines, topical and oral etc can provide relief.