Because disease states affect the relative changes in albumin and globulins in different ways, this may provide a clue to your doctor as to the cause of the change in
protein levels. A low A/
G ratio may reflect overproduction of globulins, such as seen in multiple myeloma or autoimmune diseases, or underproduction of albumin, such as occurs with cirrhosis, or selective loss of albumin from the circulation, as occurs with kidney disease (nephrotic syndrome).