ribavirin toxicity

RISK OF SERIOUS DISORDERS AND RIBAVIRIN ASSOCIATED EFFECTS "Significant teratogenic and embryocidal effects have been demonstrated in all animal species exposed to ribavirin. Therefore, COPEGUS is contraindicated in women who are pregnant and in the male partners of women who are pregnant.

After researching Tramadol last week and seeing its sx I was wondering if it was contributing to the hallucinations I was having with the interferon and ribavirin. I asked the doctor if there was any other pain med I could take after doing the research and scaring myself silly and was told no. I tried weaning off of the Tramadol, but the pain is too much to bear along with the sx of the HCV therapy, so started taking it again.

The investigational hepatitis C virus (HCV) NS4B inhibitor clemizole demonstrated synergistic antiviral activity with the HCV protease inhibitors telaprevir and boceprevir -- meaning the combined effect was greater than the added effects of the 2 drugs used separately -- without increased toxicity, according to a laboratory study published in the July 1, 2010 Journal of Infectious Diseases.

I'm on ribavirin. I have read on here that lower red cell is a good thing. I've boosted my b-12 dosage, meat, egg yolk, bean, leafy green intake to help keep mine up. am I helping or hurting my recovery by trying to keep red cell count \ up?

I took Peg-Intron + Ribavirin, Pegasus +Ribavirin, and Consensus + Ribavirin(experimental) and each time I wound up with severe bone marrow toxicity and had to inject Procrit and Neulasta one or more times per week in addition to all the other meds. Every protocol put me into remission, and every time I relapsed within 3 months.

drug_list=127-0,3323-0,728-0,2009-0,1806-1159 I plugged in the drugs you would likely be taking, Interferon, Ribavirin, Victrelis and colchicine (and also added allopurinol to see if it had any interactions). You can see that Colchicine is not a good mix with the Hep C drugs. Allopurinol seems to be okay. It is something you will have to discuss with your MD. Perhaps there is a substitute for the colchicine.

Conclusion Pulmonary toxicity is an exceptional but unanticipated complication of (pegylated) IFN/ribavirin treatment of HCV infection. Clinicians should be aware of the potential pulmonary complication related to the drug so that an early and opportune diagnosis can be made. Once evidence of pulmonary injury is demonstrated, therapy should be withdrawn immediately, and steroids may be administered if symptoms deteriorate progressively." http://www.medscape.

The pivotal ADVANCE trial randomized 1088 patients with genotype 1 HCV to receive standard peginterferon alfa-2a plus ribavirin (PR48) or a regimen of peginterferon alfa-2a and ribavirin with telaprevir 750 mg every 8 hours for the first 8 (T8PR) or 12 (T12PR) weeks of therapy followed by continuation of peginterferon alfa-2a plus ribavirin alone for a total of 24 or 48 weeks (Capsule Summary).

How did you go about taking them( Night time/right after injections/ As needed)? I know the toxicity levels for many of the opioid pain meds and that Tylenol actually has a higher hepatatoc toxicity level than say morphine or some other Opioid.

Significant teratogenic and/or embryocidal effects have been demonstrated in all animal species exposed to Ribavirin. In addition, Ribavirin has a multiple dose half-life of 12 days, and it may persist in non-plasma compartments for as long as 6 months. Therefore, Ribavirin, including Ribavirin tablets, is contraindicated in women who are pregnant and in the male partners of women who are pregnant.

Please get a complete hormone panel ESH, LH, estrogen, progesterone and see if there is an imbalance. Hormone replacement therapy will help. With metal toxicity, certain chelating agents are given which bind with the metal and remove them from the body. Normal detox diet will not take care of that. It basically increases the antioxidants in the body. Hope this helps. Take care!

Further, HCV itself contributes to mitochondrial dysfunction, which may be worsened by drugs that cause mitochondrial toxicity – including ribavirin, especially in combination with certain antiretroviral medications used to treat HIV.

During the treatment with pegylated interferons and ribavirin, we did not find a correlation between neutropenia and infections. This result provides a support for the notion that current guidelines for pegylated interferons dose reduction in the treatment of chronic hepatitis C for hematologic toxicity could be overly strict." Here are some threads voicing different opinions: http://www.medhelp.org/posts/Hepatitis-C/Need-advice-should-I-say-yes-to-neupogen/show/340785 http://www.

Here is what I found for Incivek or Victrelis in combo with Pegasys, Ribavirin and Simvastatin. Both PIs are contraindicated.

com/viewarticle/711902 November 5, 2009 (Boston, Massachusetts) — Supplementing pegylated interferon-alfa2b and ribavirin with a daily dose of vitamin D might increase virologic response rates, according to results of a late-breaking abstract reported here at The Liver Meeting 2009, the 60th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD).

(4,6) In patients with chronic hepatitis C, the addition of nitazoxanide has not resulted in an increase in the toxicity associated with peginterferon and ribavirin. Studies in patients with genotype 4 chronic hepatitis C suggest that nitazoxanide can be used to replace ribavirin.(1,2) The AIDS Clinical Trials Group (ACTG) in the United States is studying nitazoxanide plus peginterferon and ribavirin for treating chronic hepatitis C in patients coinfected with HIV.

Ribavirin toxicity

Common Questions and Answers about Ribavirin toxicity

rebetol