Ribavirin thrombocytopenia

Common Questions and Answers about Ribavirin thrombocytopenia

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1084115 tn?1385228589 The decrease in platelet count was smaller among those receiving combination peginterferon/ribavirin therapy compared with those receiving only peginterferon, indicating that ribavirin appears to mitigate thrombocytopenia due to interferon.
408795 tn?1324935675 d for the treatment of ITP but it is used off label for people (like myself) whose platelets drop (thrombocytopenia) when on Interferon based therapy for Hep C.
4043517 tn?1374006573 Promacta (eltrombopag) has been available since 2008 for ITP and has used off label by some doctors to treat thrombocytopenia in treating low platelet counts in in hepatitis C patients doing interferon based treatment. The FDA has expanded its use now to include treating hepatitis C patients. NOTE: Safety and efficacy have not been established in combination with direct-acting antiviral agents approved for treatment of chronic hepatitis C genotype 1 infection.
Avatar f tn Hi, I'm new to this site I would appreciate any information about marginal zone lymphoma (MZL) secondary to HepC infection? My partner was diagnosed with MZL in Jan 08 by surgical biopsy of a lymph node in his neck. It's a rare indolent form & most likely results from HepC infection. He has a small patch in the bone but CT scans & a PET scan revealed no other nodes in between, so is sort of stage 1 & 4 at the same time. He is 56yrs old, geno 1b, +ive for over 30 yrs.
1116669 tn?1269143266 Marc Bourlière, MD, Head of the Department of Hepatology and Gastroenterology with the Hospital Saint Joseph in Marseilles, France, and with the French National Agency for AIDS and Viral Hepatitis in Paris, stated several times that they are reluctant to lower the Ribavirin dosage in Cirrhotics due to the adverse effect it has on the SVR rates. He was quite adamant that Ribavirin dose reduction does, in fact, adversely affect SVR in Cirrhotic patients. Thanks for posting that link, Dennis.
Avatar f tn They are produced by cells in the bone marrow. Platelet counts often drop if you are on interferon and ribavirin therapy. This can put you at a higher risk for bleeding. If you have a low platelet count, you should pay particular attention to bleeding. Nosebleeds and bruises are more common. If you are concerned that you are bleeding or can't stop bleeding from a cut, seek medical attention.
Avatar f tn I got to thinking (duh) and maybe I have the neupegen thing wrong. Isn't that for low white blood cells? In my research, it looks like I have a condition called thrombocytopenia and I'm not sure there are any rescue drugs for that yet?
446474 tn?1446347682 The rates of sustained virologic response to pegylated interferon in combination with ribavirin ranged from 10% to 44% for HCV genotypes 1/4 to 33% to 72% for genotypes 2/3 in compensated cirrhosis.
Avatar f tn Hi, I'm new to this site I would appreciate any information about marginal zone lymphoma (MZL) secondary to HepC infection? My partner was diagnosed with MZL in Jan 08 by surgical biopsy of a lymph node in his neck. It's a rare indolent form & most likely results from HepC infection. He has a small patch in the bone but CT scans & a PET scan revealed no other nodes in between, so is sort of stage 1 & 4 at the same time. He is 56yrs old, geno 1b, +ive for over 30 yrs.
1579934 tn?1431268911 I received my meds from Pegasys and am going in tomorrow for my 1st peginterferon alfa-2a injection. I'm questioning the dose for the ribavirin - the bottle says 3 tabs 2x daily which = 1200mg a day. Is that a normal dose? Should I bring up my concern to the nurse tomorrow? Also in the med guide it stated that ribavirin (copegus) can cause a drop in red blood cell count, should I be concerned that my platelets are below normal now? Is it likely to cause my platelets to drop anymore?
3997096 tn?1349317861 IFN, by virtue of its bone marrow suppression effects, is known to cause thrombocytopenia, neutropenia and anemia. RBV can cause anaemia due to haemolysis as well as bone marrow suppression. Treatment-related cytopenias are more common with PEGIFN than standard IFN. Also, pre-existing cytopenias may preclude treatment with IFN. Neutropenia, while on treatment, may put the patient at risk for infections, which can be life-threatening at times.
Avatar n tn A hematologist is not the type of doctor you should have managing your possible thrombocytopenia during treatment. They have no expertise with liver disease or hepatitis C treatment. Your main health problem is hepatitis C which has caused cirrhosis of the liver. Thrombocytopenia may not be the only issue you have and it is a complication of your cirrhosis. It is not a isolated condition.
244899 tn?1313624639 Interferon and Ribavirin, Pegasys and Ribavirin and again Interferon and Ribavirin before he decided to put me on the more powerful, and in my opinion, the more unpredictable Infergen...
Avatar m tn Ribavirin is a nucleoside analog. It comes as a pill, capsule or liquid. Ribavirin is taken twice daily, and dosing is based on weight. Although it is not effective against hepatitis C when used alone, ribavirin plays an important role in HCV combination treatment. Although scientists have not discovered exactly how it works, it is clear that adding ribavirin boosts cure rates and reduces the risk of relapse.
Avatar m tn It is a autoimmune disease having an abnormally low platelet count (thrombocytopenia) of unknown origin. It occurs in children as well as adults. Peak prevalence occurs in adults aged 20-50 years. Peak prevalence occurs in children aged 2-4 years. Approximately 40% of all patients are younger than 10 years. as adults. Low platelet count (Thrombocytopenia) can be a side effect of HCV treatment drugs. Especially peg-interferon. Thrombocytopenia is also a complication of cirrhosis of the liver.
244899 tn?1313624639 Low platelets (thrombocytopenia) can result in unexplained/ pronounced bruising, and shouldn’t be ignored. They also affect blood clotting. If it were me, I’d call my treating doctor and at least get this on record; he might want to review your previous labs.
Avatar n tn Secondary thrombocytopenia is treated by eliminating the cause. Primary thrombocytopenia is treated by immunosuppressive therapies, such as prednisone, which your dog is currently on. Right now we do not know whether your dog has primary or secondary thrombocytopenia, that is why your vet has tried treating with both an antibiotic and with prednisone.
446474 tn?1446347682 The new once-daily oral medication PSI-7977 (Pharmasset), in combination with the standard regimen of pegylated interferon and ribavirin for patients infected with hepatitis C virus (HCV), cut the time for complete viral clearance in half, compared with interferon and ribavirin alone. In addition, the investigational agent was 100% effective in patients with the interleukin (IL)28B T/T mutation that has been associated with a poor response to interferon.
Avatar f tn your weakness and weight gain will begin to resolve once you stop receiving IVIG and steroids. These medications will only stop when you stop having episodes of thrombocytopenia. The thrombocytopenia will hopefully resolve once the tumor starts responding to the chemotherapy.