For serious skin reactions, including rash
with systemic symptoms or a progressive severe rash
, INCIVEK, peginterferon alfa, and ribavirin
must be discontinued immediately. Discontinuing other medications known to be associated with serious skin reactions should be considered. Patients should be promptly referred for urgent medical care.
...The presenting signs of DRESS may include rash, fever, facial edema, and evidence of internal organ involvement (e.g., hepatitis, nephritis).