Ribavirin overdose

Common Questions and Answers about Ribavirin overdose

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I’ve read that during the initial PEG-Intron trials, a patient intentionally ingested 10 grams ribavirin without any major problems. I sure wouldn’t want to try that, but it demonstrates the threshold of toxicity is way up there. I used to have that link saved, but I’m unable to locate it now; if I find it, I’ll post. Are you using a pill box? They really help to keep track of your meds; they can be found in almost any drug store.
Have you had previous experience with 1600 mg/day of ribavirin? If not, you might start sooner and titer up more gradually to make sure that you can handle the dose. Keep in mind that it can take 1-3 weeks for a change in ribavirin dose to be reflected in your hemoglobin. Also, and again based on your previous treatment experience, consider Procrit (epo) coincidental with the riba pre-dosing for same reasons.
I take ribavirin twice a day. I just cannot remember if I took tonight's dose or not. Is it better to: 1. take a dose (which may mean I had a double dose), or 2. just assume I did take it (which may mean I totally miss a dose). Main anxiety is I have VERY low platelet count and am monitored weekly to ensure it doesn't drop at all (it's borderline). And I THINK that part of what the ribavirin does is to counteract the interferon's thinning of the blood. It is 10.
//www.drugs.com/sfx/ribavirin-side-effects.html ----------------------------- So to answer your question, yes it is listed as a side effect as is clinical depression...............
i'm currently on tx pegasys and ribavirin. my neutrophils are pretty low so i asked my PA if i should take multivitamins. she told me that i should already be taking multivitamins. would it be safe for me to take Centrum Performance multivitamins containing: - 100% Iron - 70% Vitamin A - 200% Vitamin E ?
At this time, it is not entirely known what to expect from an INCIVEK overdose. However, the effects of an overdose would likely vary, depending on a number of factors, including the INCIVEK dosage and whether it was taken with any other medications or substances.
I don't want to overdose I can't believe I did this -- I had the pills sitting in front of me while on computer and got so involved reading and forgot --looked up at 6:30 and theres the pills sitting on desk. ****!
Interferon and Ribavirin, Pegasys and Ribavirin and again Interferon and Ribavirin before he decided to put me on the more powerful, and in my opinion, the more unpredictable Infergen...
By then I had decided that I didnt want to take the extra risk of inf overdose , and just went for a riba overdose only; and he said no to that at first as well but soon afterward he approved that too. Considering your profile, the inf overdose might be justified and worth it. Talk him into it. He will approve it when he sees you are set on it. In the pecking order, i see riba as the first line of greater attack so make sure and do that along with the the inf overdose.
Anemia has been reported with peginterferon alfa and ribavirin therapy. The addition of INCIVEK to peginterferon alfa and ribavirin is associated with an additional decrease in hemoglobin concentrations. A decrease in hemoglobin levels occurred during the first 4 weeks of treatment, with lowest values reached at the end of INCIVEK dosing. Hemoglobin values gradually returned to levels observed with peginterferon alfa and ribavirin after INCIVEK dosing was completed.
For more than 20 years I did not know that. Since 2006 I tried three Interferon/Ribavirin therapies. 24, 48 and 72 weeks. With no result, still relapsing. The first two therapies passed with no further complications. Business as usual regarding side affects. But the last therapy ended up in a mess. Around week 55 all my muscles started to contract heavily and left me with permanent pain until week 67 when I had to quit the treatment for that reason.
overdose of ribavirin although rare can be fatal esp if other conditions are present - I've never heard of a ribavirin overdose. If memory serves,I did read in the ribavirin fda approval notes where one patient took 50 pills..no overdose.
(If you follow the links, go down to the section that says side effects for the professional: http://www.drugs.com/sfx/ribavirin-side-effects.html "The most common serious adverse event (3% in CHC and 5% in CHC/HIV) was bacterial infection (e.g., sepsis, osteomyelitis, endocarditis, pyelonephritis, pneumonia).
[33] In the second study, patients with a previous nonresponse to standard interferon and ribavirin were retreated with peginterferon alfa and ribavirin.[34] Overall, 28% of patients in this study achieved an SVR. However, 75% of these patients had a partial virologic response during the initial course of treatment.
It's hard to treat - Hepatitis C is a particularly tenacious virus, hence the vast resources the pharmaceutical industry has plunged into improving their weapons against it. For decades, the standard treatment for Hepatitis was interferon and ribavirin - a drug combo that effectively eliminated the virus in about 50 percent of patients. New medications recently approved are expected to increase those odds; however, Hepatitis C is still extremely adept at evading treatment.
The chemical medicines are very bad. We should not overdose with them. Some people committed suicide from the ribavirin. It is very toxic. Best wishes for your mom with kick starting her immune system. She might try acupuncture. I just stopped tx 2 weeks ago so I'm not an expert on post tx. I took the medicine for 51 weeks. I also took Dr. Zhang's herbs that help normalize the liver (stop inflammation) and reduce the side effects. They are costly but what price your way of life?
actually, I've brought this one up before too. I'm excited about the concept of phlebotomy used with HCV meds as a way to possibly shorten treatment protocols. There is a Japanese company that has patented a machine they feel would work well in delivering this type of medication protocol. I posted on it before, too tired to go look for it at the moment.
Some may take it as an adjunct to treatment but doctors here in America just give us that old nasty interferon and ribavirin. Procrit for low hgb and Neupogen for low ANC. Doubt milk thistle or shark oil could produce the same results.
If you've followed my progress regarding the dangers of Infergen overdose, I wanted to post the post treatment condition as of now. Although I was told to try overdosing by my Gastro, and I was brought to a near death liver failure situation, I feel I've fully recovered, but with some lingering effects.
Hi All, I haven't posted in a while because I have been "adjusting" to Tx. First three weeks not bad at all (minor sides) but this last week my Hemoglobin went from 14.5-11.1 and then today dropped to 10.0. I feel weak, dizzy, and like I'm sucking air! So my nurse called and I have to see a hemotologist on Monday for "rescue drugs." (Will I make it till Monday?) She also reduced my Ribavirin to 800 mg instead of 1000. Will that affect my Tx results?
Seek emergency medical attention if an overdose is suspected. Symptoms of interferon alfa-2a overdose are not well known but may include decreased appetite, chills, fever, and muscle aches." I am on Pegasys and the dose is supposed to be fixed but there is no doubt 180 mcg was too much for me. To get to your question, I had to either stop treatment altogether or reduce the dose. I really want to get rid of this thing so I decided, along with my doctor, to reduce the dose.
so I was able to stop one Ribavirin but that was after 30 weeks of treatment. 5 a day was an overdose. My treatment is weight based. I still take the same shot. I'm Geno 1a. Undetectable since week 15. Do you know your stage of liver disease. If you are a 0, 1 or 2 you can wait for the new meds coming out in 2-3 years. It looks VERY promising. You find out your stage from the biopsy. Good luck on what you decide. We are always here for you.
30 p.m. Two hours later I hardly feel anything. It’s not like the past three treatments. Just a little dizzy and warm breath until four hours later. I started shaking slightly with the chills, then more and more. After three blankets and a heating pad, I was still shaking very badly, teeth chattering for one hour. I went to get an 800mg pill of Ibuprofen and I could hardly walk to the medicine cabinet. My left hip was extremely painful from the medicine.
I'm genotype 1a and was a non responder in 2002, I took peg/intron A (scheering-plough) with ribavirin. Now my hepatologist is prescribing the triple therapy (pegasus - ribavirin) with incivek. My question is, if i failed on peg/intron A with ribavirin before is this the right prescription? thanks!
-------------------------- Actually, she may be wrong according to newer findings by the Sweedish researcher Lindahl regarding the saturable nature of ribavirin. What Lindahl found is that Higher ribavirin doses are associated with a lower bioavailability and therefore recommended 3X a day dosing for those on high dose ribavirin (HDV) which I believed was defined as over 2000 mg/day.
Have found great insight and information, also comfort in knowing I’m not going through this alone. Thanks all! Am geno 2b doing 24 wks Peginterferon alfa-2a/Ribavirin, 60yrs old, at 6’3”, starting treatment at 238lbs, 2,368,000 Viral Load, UND at 4 weeks, TMA negative. Have been doing max 1200mg riba/day, 180mcg interferon/wk since beginning tx. Still UND at 9weeks. Am now at 224lbs.
[Contact Lloyd] INF hastens liver damage… Nonresponders to Interferon-based Treatment of HCV Exhibit an Increased Long-Term Hazard of Cirrhosis Compared to Never Treated 4/3/2013 The long-term consequences of failed interferon-alpha based hepatitis C treatment on liver morbidity and survival have not been fully… I have been denied Long term disability because they cannot prove that I have pain 3/25/2013 from Barbara via Ask Lloyd I was diagnosed with Hep C in 2006, did
5 years 1) with regular interferon and ribavirirn 48 weeks 2)Peg-Intron and ribavirin 52 weeks and 3)Pegasys and ribavirin for 73 weeks. I reached SVR the last time around and stopped TX June 2004. I used insulin throughout the TX and controlled my diabetes tightly. If you are clear 1 year post TX you should be fine and the treatment of diabetes should pose no risk. Graves I am not prpared to discuss but the diabetes should not be a problem as far as your SVR goes.
Ribavirin is not always weight based contrary to what many people think. Geno 2's And 3's using peg alpha 2a use 800 mg's a day. http://www.drugs.com/dosage/ribavirin.html Just thought I'd throw that in there.
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