ribavirin monotherapy

Pegasys is not used as a monotherapy in hep C patients. If he is taking it with ribavirin that would be for hepatitis C. People with pregnant partners should not use ribavirin during their partners pregnancy. Interferon alone is sometimes used for hairy cell leukemia, kidney cancer and melanoma. It is not used for liver damage as a monotherapy since it was proven that it does not help the liver recover from damage due to any reason.

PEG-IFN-2a and ribavirin for 48 weeks (n=40), nitazoxanide monotherapy for 12 weeks, followed by nitazoxanide plus PEG-IFN -2a for 36 weeks (n=28), or nitazoxanide monotherapy for 12 weeks, followed by nitazoxanide plus PEG-IFN-2a and ribavirin for 36 weeks (n=28). , The percentages of patients with RVR and SVR were significantly higher in patients receiving triple therapy than in those receiving the standard of care (64 vs. 38%, P=0.048 and 79 vs. 50%, P=0.023 respectively).

If not, perhaps you should wait for the protease inhibitors. However, even those are done with ribavirin. You might look into studies that do not use ribavirin.

1 We started first a monotherapy with ribavirin to evaluate the highest tolerable dosage and also to reach a steady-state plasma ribavirin level before starting silibinin and pegylated interferon-alfa. During the 4-week ribavirin monotherapy (800 mg/d) a 0.6-log drop in viremia was observed (from 1,610,000 to 363,330 IU/mL; Figure 1).

Nevertheless, this viral kinetic parameter has been estimated comparing the viral kinetics in patients with interferon-α monotherapy and interferon-α plus ribavirin combination therapy (41, 42). If ribavirin mainly blocks viral production, estimated treatment efficiencies on blocking viral production should be higher in patients treated with combination therapy than in patients treated with interferon-based monotherapy.

I believe Zoogie did 73 weeks of monotherapy due to allergic reaction from ribavirin. Genotype 3 Hope the future drugs will give more promising results for those that can't take the ribavirin Zoogie. Enjoy everyday and keep an eye open for better treatment options.

Yes both PSI 7977 and PSI 938 are both being tried as monotherapies. But it will be a long time before our trials are done dosing and have achieved SVR (6 months later). How are you doing Susie? Are you in Quantum?

Several folks on this site are doing it with SOC - they preload it. I was going to but have Enbrel as my 3rd drug. Here is some info Slide show http://www.informedhorizons.com/hepdart2007/pdf/hepdart07_presentations/Tues_04_Korba.pdf This is a trial with Geno 4 Alinia Phase II Study Shows that Nitazoxanide Significantly Improves Response to Standard of Care in Patients with Chronic Hepatitis C http://www.earthtimes.org TAMPA, Fla., Nov.

I was wondering any information you might have regarding svr and the ribavirin dose reduction (i did see a study regarding monotherapy with a viral load of less than 100,000 and genotype 2 here is the link http://www.ncbi.nlm.nih.gov/pubmed/19084937 any insight will be greatly appreciated.

Although combination therapy with interferon (IFN) plus ribavirin is the standard of care for chronic HCV infection, IFN monotherapy is recommended in dialysis patients because ribavirin is contraindicated in the presence of renal failure.

Fueloep and colleagues retrospectively analyzed the effect of ribavirin monotherapy followed by standard combination therapy (pegylated interferon plus ribavirin) on initial decline in HCV viral load and overall treatment outcomes. Addition of ribavirin reduces the risk of relapse after completing treatment, and therefore increases the likelihood of sustained virological response (SVR) to interferon-based therapy.

Silibinin Milk Thistle Derivatives Demonstrates Antiviral Activity in Non-responders to Interferon-based Therapy for Chronic Hepatitis C Patients By Liz Highleyman Given that about half of patients with genotype 1 chronic hepatitis C virus (HCV) infection do not achieve a sustained response to standard pegylated interferon/ribavirin therapy, researchers have explored other types of treatment including various alternative or complementary therapies.

004) In this study genotype 2 treatment naive patients achieved a mean 4 log reduction in viral load after 6 days on monotherapy with telaprevir. The triple combination of telaprevir + peg/RBV achieved a mean 5.3 log reduction in viral load at day 16. But genootype 3 patients only achieved a -.80 reduction in viral load so therapy for genotype 3 won't be pursued.

Maybe you should go to pubmed and read a little bit about txing while being on dialysis. Those meds go thru every organ you can think of including your kidneys. I can't think of any current tx that excludes the use of Ribavirin. Maybe you can get into a trial, whatever you decide I hope your doctor knows what he's doing. Also just to use the IFN doesn't work, here’s a link that is current.

2 DOSAGE AND ADMINISTRATION SOVALDI should be used in combination with ribavirin or in combination with pegylated interferon and ribavirin for the treatment of CHC in adults.

t understand why, instead of follow-up trials of ITMN-191 (R7227) as monotherapy, the developer has switched to a ITMN-191 + SOC trial? Was there some biomedical reason for this, or is it political pressure, bribery, or what?

I have Type-2. I have done a 24 week TX and failed. Then around a year break and a 48 week which failed. Both times I responded but could not sustain. So now I'm on the interferon @ 1/2 dose and responding but with less then half the sides. The plan is to continue until early 2011 when a new treatment testing will be completed and released. It's basically the same but with an added element.

s simply completing the last week of treatment on *full dose riba* as each week starts with an injection followed by six days of ribavirin. Tapering ribavirin would be to decrease the daily dose of ribavirin from full dose to progressively smaller increments, until eventually stopped.

The only US Food and Drug Administration-approved treatment for hepatitis C is combination therapy with pegylated interferon alfa and ribavirin (standard of care), which leads to a sustained virologic response (SVR) in approximately 80% of patients infected with hepatitis C virus (HCV) genotype 2, approximately 60% to 65% infected with genotype 3, and approximately 40% of patients infected with HCV genotype 1.

to demonstrate the retinal complications of interferon monotherapy and interferon plus ribavirin on patients with chronic hepatitis patients & Methods: 22 patients with chronic hepatitis C diagnosed by PCR were classified in to two groups. Group I which included 13 patients , 8 were not diabetic or hypertensive (Group Ia) and 5 patients were diabetic and/or hypertensive (Group Ib). Patients of this group were given Interferon alpha2b monotherapy for 24 weeks.

Ribavirin monotherapy

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