Ribavirin contraindications
Common Questions and Answers about Ribavirin contraindications
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In addition, Ribavirin has a multiple dose half-life of 12 days, and it may persist in non-plasma compartments for as long as 6 months. Therefore, Ribavirin, including Ribavirin tablets, is contraindicated in women who are pregnant and in the male partners of women who are pregnant. Extreme care must be taken to avoid pregnancy during therapy and for 6 months after completion of therapy in both female patients and in female partners of male patients who are taking Ribavirin therapy.
Extreme care must be taken to avoid pregnancy in female patients and in female partners of male patients as significant teratogenic and/or embryocidal effects have been demonstrated in all animal species exposed to ribavirin [see Contraindications (4), Use in Specific Populations (8.1), and Patient Counseling Information (17.1)]. Refer also to the prescribing information for ribavirin.
All I can tell you is, my hepatologist told me not to take it while I was treating. I know it weakens your immune system, can raise your BP (and so can Sofosbuvir), etc.
I would consult with your physician and the prescribing pharmacist for Sofosbuvir. Gilead's support will not be of much help. They will read you a list of known contraindications but will not advise on specific medications as you're inquiring about.
I cleared in the trial on Viekira Pak. There were no contraindications (except alcohol) or requirements to eat anything special. Some people find it helpful to eat if you are taking ribavirin and it is bothering your stomach. I had absolutely no problems.
RISK OF SERIOUS DISORDERS AND RIBAVIRIN ASSOCIATED EFFECTS
"Significant teratogenic and embryocidal effects have been demonstrated in all animal species exposed to ribavirin. Therefore, COPEGUS is contraindicated in women who are pregnant and in the male partners of women who are pregnant.
Significant teratogenic and/or embryocidal effects have been demonstrated in all animal species exposed to ribavirin. In addition, ribavirin has a multiple dose half-life of 12 days, and it may persist in non-plasma compartments for as long as 6 months. Therefore, ribavirin, including Copegus, is contraindicated in women who are pregnant and in the male partners of women who are pregnant.
Because INCIVEK must be used in combination with peginterferon alfa and ribavirin, the contraindications and warnings applicable to those drugs are
applicable to combination therapy. Female patients of childbearing potential and their male partners as well as male patients and their female partners must use 2 effective contraceptive methods during treatment and for 6 months after all treatment has ended.
Because Incivek must be used in combination with peginterferon alfa and ribavirin, the contraindications and warnings applicable to those drugs are applicable to combination therapy. Female patients of childbearing potential and their male partners as well as male patients and their female partners must use 2 effective contraceptive methods during treatment and for 6 months after all treatment has ended.
A Multicenter Compassionate Use Protocol of Daclatasvir (BMS-790052) in Combination With Sofosbuvir With or Without Ribavirin for the Treatment of Subjects With Chronic Hepatitis C
http://clinicaltrials.gov/ct2/show/NCT02097966
Excerpts
Expanded access is currently available for this treatment.
I took the Sovaldi @ 8:00 am along with 3 Ribavirin, with food, usually a couple of large tablesppons od plain greeklike yogurt, some fresh fruit of some sort, and almonds. At night @ 8:00pm I took the other 3 Riba, also with a light, liver friendly, meal.
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Significant teratogenic and/or embryocidal effects have been demonstrated in all animal species exposed to Ribavirin. In addition, Ribavirin has a multiple dose half-life of 12 days, and it may persist in non-plasma compartments for as long as 6 months. Therefore, Ribavirin, including Ribavirin tablets, is contraindicated in women who are pregnant and in the male partners of women who are pregnant.
m having a terrible time finding information on post-treatment SVR female patients who have become pregnant or are trying to become pregnant. I am aware of all the contraindications during treatment and six months post-treatment. But I haven't been able to find anything past that time frame.
Does anyone have any links or resources they can point me to? It'd be greatly appreciated.
Here's to SVR for everyone.
thanks very much. are there any contraindications for this combination?
There are no contraindications for Ascites with regards to taking Harvoni. It should not make your condition worse or affect it in any way.
It is a very well tolerated medication.
Patients with anti-HCV, HCV RNA, elevated serum aminotransferase levels, and evidence of chronic hepatitis on liver biopsy, and with no contraindications, should be offered therapy with the combination of peginterferon and ribavirin. The National Institutes of Health Consensus Development Conference Panel recommended that therapy for hepatitis C be limited to those patients who have histological evidence of progressive disease.
1) 6,720 Iu/ml ( 34,956 copies/ml) on 29 July 2004
2) 1.9 X 106 copies / ml 0n 21 December 2004
3) Less than 10,000 copies / ml on 23 July 2005
4) 1.47 X 105 IU/ml in May 2007
and her ALT is :
1. 31 u/l on 17 July 2004
2. 24 u/l on 30 August 2004
3. 29 u/l on 30 October 2004
4. 31 u/l on 20 May 2005
5. 28 u/l on 18 March 2006
6. 24 u/l on 13 December 2006
7. 31 u/l on 16 April 2007
We have conducted ultra sound and it shows that her liver is clear.
I am genotype 3 on treatment for 24 weeks with sofosbuvir and ribavirin. I am currently on day 49 and so far have not been able to return to work. The side effects seem to wax and wane, but so far am still struggling. My doctor says after six to eight weeks it should get better, but so far not the case for me and I cannot imagine doing this another for months.
The best results for HCV are obtained with pegylated interferon-alpha in combination with the antiviral drug ribavirin. Sustained response (cure) is obtained in 40% (genotype 1) to 85% (genotype 2 or 3) of treated patients. Interferon-alpha has many side effects, and the selection of patients for treatment should be made taking into consideration the individual prognosis and relative and absolute contraindications. New biologics are in clinical development.
Why was it suggested? Who suggested it to you?
This supplement seems like it's designed for bodybuilders. It's not regulated by the FDA, so a pharmacist may not have information on contraindications. Still, a call to your Copaxone pharmacy as well as your PCP are in order.
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