Ribavirin and pregnancy
Common Questions and Answers about Ribavirin and pregnancy
rebetol
in hamsters, ribavirin was associated with defects of the limbs, eyes, and brain; in rats, defects of the brain and eyes predominated -- but these were experiments exposing bone marrow cells. Because of its frequent association with adverse effects on pregnancy in animal experiments, the marketing approval of ribavirin specified that it be avoided in women or girls who are pregnant or may become pregnant within four weeks after exposure to the drug.
Ribavirin has a longer half life than interferon. The levels for both gradually come down to zero over time. It is a few weeks with interferon and a few months with ribavirin.
Ribavirin causes fetal death and deformity in lab animals. To get an idea of the seriousness of exposure, go to http://www.ribavirinpregnancyregistry.com/dlfiles/2009/RibavirinPedBirthDefectVersion1.1.pdf
An OB probably knows about these issues but may need to consult with the doctor who treated your HCV. This is a terribly serious issue. Good luck.
Ribavirin Pregnancy Warnings
Ribavirin has been assigned to pregnancy category X by the FDA. Nearly all animal studies have revealed evidence of embryolethality and teratogenicity. There are no controlled data in human pregnancies. One published case reports the uneventful use of ribavirin at 33 weeks gestation. Ribavirin therapy is contraindicated in women who are pregnant and in the male partners of women who are pregnant.
The absorption was slowed (Tmax was doubled) and the AUC0-192h and Cmax increased by 42% and 66%, respectively, when Ribavirin tablets were taken with a high-fat meal compared with fasting conditions [see Dosage and Administration (2.1) and Patient Counseling Information (17)].
http://www.drugs.com/pro/ribavirin.
Hi. I just found this site and it looks great. My husband has HCV and CKD. His neph says the kidney problem is caused by the HCV, but last year he had one of his kidneys removed because of cancer. So I wonder. My real concern is that R. won't be able to take the HCV meds because I often read that it's very bad for the kidneys, and he's only got one that's in bad shape. Found the HCV accidentally and we think he's had it for over 30 years.
In addition, Ribavirin has a multiple dose half-life of 12 days, and it may persist in non-plasma compartments for as long as 6 months. Therefore, Ribavirin, including Ribavirin tablets, is contraindicated in women who are pregnant and in the male partners of women who are pregnant. Extreme care must be taken to avoid pregnancy during therapy and for 6 months after completion of therapy in both female patients and in female partners of male patients who are taking Ribavirin therapy.
Harvoni and Ribavirin for 24 weeks. Hgb dropped two points after two weeks, still not technically anemic as I started with good Hgb levels, though feeling tired. Dr. reduced Ribavirin to 600mg from 1,200mg. Hoping it will level off as I would like to continue the Riba. Dr. had been to recent CROI conference and mentioned that although the benefits of Riba are not fully understood, it does seem to have some advantage when used in conjunction with Harvoni.
I am 5 weeks into Sovaldi/Ribavirin treatment and all is going very well. I have been undetected since week two and I feel fine. I am cross country skiing in the Vermont mountains 3-4 times a week and feel good, maybe a little off but then I have been skiing quite a bit lately. I was out yesterday with a bunch of guys 10-20 years younger than me and I was the one waiting at the top of the climbs. The nurse practitioner at the hepatology department said I should exercise all I want.
Recommended
