Ribavirin adverse effects

Common Questions and Answers about Ribavirin adverse effects

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7593014 tn?1414212474 Not sure about PEG In the trials only 2% getting your tx had to quit because of adverse events but those who took the same for 24 weeks 11% had to stop The proportion of subjects who permanently discontinued treatment due to adverse events was 4% for subjects receiving placebo, 1% for subjects receiving SOVALDI + ribavirin for 12 weeks, < 1% for subjects receiving SOVALDI + ribavirin for 24 weeks, 11% for subjects receiving peginterferon alfa + ribavirin for 24 weeks and 2% for subjects r
Avatar m tn As far as Sofosbuvir + Ribavirin there is no associated mental effects such as clinical depression. Clinical depression is a side effect of peg-interferon as in mentioned in the product label of all interferons NOT Ribavirin. The data on side effects is available for most trials that are completed at this time and that Gilead submitted to the FDA for treatment approval.
Avatar m tn http://www.ncbi.nlm.nih.
Avatar f tn Refer to the prescribing information of peginterferon alfa and ribavirin for a description of adverse reactions associated with their use. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
Avatar m tn [24] Therefore, it is the recommendation of this author to reduce ribavirin stepwise by 200 mg every 2-4 weeks until adverse events either resolve or are tolerable. Peginterferon alfa-2a can be reduced from 180 to 135 µg/week and peginterferon alfa-2b from 1.5 to 1.0 µg/kg/week. Neither peginterferon alfa nor ribavirin dosing should be interrupted unless the adverse event is particularly severe and there is a concern for patient safety.
Avatar m tn hello my friends. my gastro doc just called and informed me that she had a new 2 drug pill combo(ribavirin and something else) 12 week course of treatment.she didn't elaborate but i'm excited about this new option.does anyone have an idea about the second drug and any other info would be appreciated.i cleared the virus in 2011 after the standard interferon riba 6 mos course of drugs,but it came back 1 month later (genotype 2) thanks Curt.
Avatar f tn My doctor was disappointed but hoped it would be at zero with another month. Everything I saw on the forum showed undetectable at 4 weeks and some at 2 weeks. I had no blood work until 4 weeks, so was hoping for the best at that time. My side effects were minimal, the worst being insomnia. The first couple of weeks I felt sort of "drugged" but nothing like the interferon/ribavirin routine. That was horrible and I did not last long on it.
7510956 tn?1411671417 There are other treatments but you will need to take peg-interferon and ribavirin and possibly have some difficult side effects during treatment? You can stop the liver damage it has been causing for decades. In my opinion you should serious think about treating your hepatitis C now while your liver damage is still reversible. Treatment was generally safe and well tolerated.
Avatar f tn "Gilead Sciences Inc. discontinued dosing of a four-drug HCV regimen consisting of tegobuvir (GS 9190), ribavirin, pegylated interferon and either GS 9451 or GS 9256. Gilead said the regimen led to two serious adverse events in two separate studies. The company did not say how many trials would be affected but added that the timelines of the studies will remain unchanged. Dosing regimens that include GS 9190 but not interferon will continue as planned." http://www.bioportfolio.
Avatar m tn we have posted before about hair loss with ribavirin/interferon combo and I posted about loss of hair, skin sensitivity and changes and reaction to the sun. The bumpy rash was also part of it and even today there is a bit of this bumpiness on the front part of my forearms where hair fociles would have been. Have been to derm who specializes in this area and he did take it back to the drugs,the liver & residual side effects from adverse reactions to combo therapy. Reports aside...
Avatar f tn [34-37] Despite these challenges, previous studies have shown that HCV treatment generally was well tolerated by the elderly and there was little or no significant difference in SVR as well as therapy discontinuation rates secondary to adverse effects compared with younger age groups. However, there is a need for prospective randomized controlled trials to be conducted in HCV patients older than 65 years of age to better evaluate the safety and efficacy of HCV treatment in this age group.
Avatar f tn in rats, defects of the brain and eyes predominated -- but these were experiments exposing bone marrow cells. Because of its frequent association with adverse effects on pregnancy in animal experiments, the marketing approval of ribavirin specified that it be avoided in women or girls who are pregnant or may become pregnant within four weeks after exposure to the drug. In terms of real human exposures, there HAVE been case reports of NORMAL outcomes in pregnancy from exposed parents.
Avatar m tn The safety and tolerability profile of telaprevir in the ADVANCE trial was consistent with the profile reported in Phase 2 studies, with an improvement in treatment discontinuation rates due to adverse events. Adverse events leading to discontinuation of all study drugs occurred in 6.9%, 7.7% and 3.6% of patients in the 12-week telaprevir-based arm, the 8-week telaprevir-based arm and the control arm, respectively.
Avatar f tn My mom is 56, she has got Hep C genotype 1a and she is going to start triple therapy on Monday, 12th of May. More I read about the side effects, more I scared... Any suggestion from people who has gone through this?
Avatar m tn sofosbuvir/velpatasvir without ribavirin (97%); sofosbuvir plus daclatasvir with ribavirin (96%); and sofosbuvir with peginterferon plus ribavirin (95%). Among patients with cirrhosis, more achieved SVR when they received sofosbuvir/velpatasvir (96%) or sofosbuvir/daclatasvir plus ribavirin (94%) for 24 weeks, and sofosbuvir/velpatasvir plus ribavirin for 12 weeks (94%). “The key finding is that sofosbuvir/velpatasvir regimens achieve the highest efficacy in HCV genotype 3.