Ribavirin action

Common Questions and Answers about Ribavirin action

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Avatar m tn In order to further characterize the mechanisms of action of ribavirin, we examined the effect of ribavirin treatment on ISG induction in cell culture. In addition, the effect of ribavirin on infectious HCV cell culture systems was studied. Similar to interferon (IFN)-α, ribavirin potently inhibits JFH-1 infection of Huh7.5.1 cells in a dose-dependent manner, which spans the physiological concentration of ribavirin in vivo.
Avatar m tn From Clinical Use Back to Molecular Mechanisms Posted 12/08/2008 "Ribavirin is an old broad-spectrum antiviral that is highly effective when used in combination with interferon-α and also as part of triple therapies containing new inhibitors of the hepatitis C virus (HCV) non-structural (NS)3/4 protease or HCV NS5B polymerase for the treatment of patients with chronic hepatitis C.
Avatar m tn Ribavirin Mode of Action in Chronic Hepatitis C: From Clinical Use Back to Molecular Mechanisms Wolf Peter Hofmann; Eva Herrmann; Christoph Sarrazin; Stefan Zeuzem Authors and Disclosures Published: 12/08/2008 ".....Despite the presence of conflicting results, accumulating data from several in vivo studies support the concept of ribavirin-induced HCV mutagenesis as a possible mechanism of action in patients with chronic hepatitis C. However, several precautions should be taken.
Avatar m tn Greater than 1000 IU/mL Action-Discontinue INCIVEK and peginterferon alfa and ribavirin (INCIVEK treatment complete at 12 weeks HCV RNA-Week 24: Detectable Action-Discontinue peginterferon alfa and ribavirin http://pi.vrtx.com/files/uspi_telaprevir.
Avatar f tn Skin Problems Pegylated interferon plus ribavirin are associated with skin problems like itching, dry skin and eczema. However, Hepatitis C protease inhibitors (especially telaprevir) increase the frequency of these side effects: An estimated 55 percent of those on telaprevir (with interferon and ribavirin) develop a rash. An estimated 33 percent of those just taking pegylated interferon and ribavirin develop a rash. http://www.hepatitis-central.
Avatar m tn if it gets much lower than that, your doctor will usually take action. Your options are to either dose reduce the ribavirin or begin Procrit (epo) therapy. If it becomes *too* low (<8.5, generally), they will transfuse as an emergency intervention. The best scenario is to request Procrit if needed. Try to maintain full dose ribavirin for the best shot at eventual SVR. Do you have a history of cardiovascular disease? If so, your doctor might want to exercise additional caution.
Avatar n tn s, are vulnerable to bladder infections from intercourse due to the action of intercourse rubbing against the urethra. It has nothing to do with either condoms or pegasys. Drinking cranberry juice on a regular basis is a very good prophylactic (prevenative) measure, and I'm going to give you two other great prevenative measures that only a very good urologist will tell you.
1752948 tn?1466354161 Among Japanese patients who received telaprevir + peginterferon + ribavirin, Akuta and colleagues reported an SVR rate of 83% for subjects carrying rs12979860 C/C as compared with 32% among subjects who carried a T allele.
8683847 tn?1410757316 Good ole Ribavirin. What your having is pretty common. Wishing you the best.
Avatar n tn t really seem to have many more SX with Victrelis than he had with just Interferon and Ribavirin. At least nothing that has bothered him a whole lot more than the other.He is cirrhotic, by the way. He gets plenty of SX with plain old Interferon and Ribavirin but Victrelis hasn't made it much worse, and it is actually and finally, doing the job.
4670047 tn?1375730401 I was just wondering how long some of you took the ribavirin after your last shot. I'm going to call the Dr. On Monday and ask. But I'm just a little anxious, my last shot is Mon. night. Thank you!
Avatar n tn How long that ribavirin stay's in my system after doctor tells me my bloodwork came out good and i can get of that medizin.
Avatar n tn I am running short on my Ribavirin. Does anyone know of any resources? What would be the least expensive way, assuming that my doc won't give my Rx.
Avatar f tn s decision of approval status is expected by May 23, 2011. I hear that this med in combination with the pegylated interferon and ribavirin could boost the sustained response rate above 70%..
Avatar n tn Careful with taking antacids containing magnesium, aluminum, and simethicone (Mylanta) with Ribavirin - resulted in a 14% decrease in mean ribavirin absorption. Some link to other threads if interested: http://www.medhelp.org/posts/Hepatitis-C/Heartburn/show/91910 http://www.medhelp.org/posts/Hepatitis-C/Indigestion-and-heart-burn/show/1481205 http://www.medhelp.org/posts/Hepatitis-C/Ribavirin-antacids-Drug-Interactions/show/90533?
Avatar m tn It is approved for treatment of cryptosporidiosis and lambliasis in the United States. In vitro nitazoxanide was shown to inhibit HCV replication and the mechanism of action was proposed to be induction of double-strand RNA activated protein kinase.118 In a placebo-controlled study monotherapy with nitazoxanide for 24 weeks led to a mean reduction of HCV-RNA viral load in genotype 4-infected patients by 1.55 log10 IU/mL with 30% of patients having undetectable HCV RNA at the end of treatment.