For me this has made the shots pain-free. I don't inject
my arms; my thighs are the biggest challenge, but the Rebif
nurse suggested going high up on the thighs, and towards the outside -- that has halped a lot. Belly shots seem creepy, but there's a good fat pad there, & are really fine.
I do get red spot a couple of days after each shot, and it stays for 2-3 weeks, but no pain or itching.