At least with the Interferons, they are a once a week injection (I think
Rebif is like Avonex, once a week) You may have some slight
injection site reactions, in that you will get a slight raised area (maybe) and some feverish feeling at the the injection site, but I found when I was on Avonex, that it was a very short-lived reaction.
Don't wait too long before you start back on some type of DMD. With the Interferons, they must be kept refrigerated until you are ready to use them.