I was on Zoloft for depression for about 6 months after trying Prozac
, Effexor, and a bunch of different combinations of sedatives, sleep aids, and antipsychotics. I was up to 300 mg, but the side effects, including horrible headaches, insomnia, nightmares, GI upset, and emotional numbness, never went away. I started to taper down with my psychopharmacologist's help. I tapered down to 50 mg, but my psychopharmacologist didn't want me to completely go off of it.