I've had depression/anxiety for 10 yrs now. I've been off and on Prozac (only drug I've ever tried). I was on 10mg-20mg Prozac for the last 2 years, until 6 weeks ago. I weaned myself off. This is the reasons why: I gained 40 pounds in 2 yrs on it, and I still had a great amount of depression and anxiety. And so far, I really haven't been worse off it, about the same. But I'm tired of the battle, the daily battle. I'm totally different now then what I used to be.