Hello, thanks for asking you
I am not aware that a PPI can
suddenly stop working. However, there are cases where GERD are refractory to optimal PPI treatment. For intance, GERD can
"breakthrough" optimal PPI therapy. Up to 70 percent of patients taking PPIs twice daily
will have periods of gastric pH <4 lasting for more than 60 minutes, particularly at night. Nocturnal acid breakthrough may be responsible for the majority of patients with refractory GERD.