Additionally, it carries many drug-drug
interactions, particularly when combined with psychiatric drugs.
Propranolol is the prototype for the beta-blocker class. It tends to easily cross the blood-brain barrier, and may induce depression or worsen pre-existing depression. Others in this class carry a much lower incidence of psychic disturbance and few or no drug-drug interactions (Atenolol, Metoprolol, Nadolol and Timolol) are four examples. There are other benefits.