prograf vs tacrolimus

there are prograf assistance programs that the company offers. If this is not feasible than using other cheaper medications such as verapamil for example for HTN for example will alllow much lower doses of prograf to be used (it delays metabolism of the medication) and thus it comes out cheaper.

His cretanine is almost 1.4 or around. My question is that should he continue his TACROLIMUS tablets or should switch to some other tablets which are safe for kidneys? Secondly , in my sorrounding there is an opinion that lowering the TACROLIMUS dose also let the liver enzymes to increase? Do you favour such opinions as my father has lowered his tacrolimus dose to keep his kidneys safe? Sir ,will wait for your kind reply. Thanks.

i wouldnt lower the tacrolimus dose further

I take Prograf for the liver transplant and I know Naragenin affects the Prograf levels. My question is if during treatment I also took Naragenin and my prograf levels were closely watched and adjusted for the Naragenin effects, wouldn't I have a better chance of clearing the virus.

I'm geno type 3. I've heard Prograf is harder on the kidneys than sirolimus which is why they switched me from cyclosporine to sirolimus. That's probably why they haven't suggested switching me to Prograf in fact this is the first time I'm hearing about Prograf or Tacrolimus (it's other name as I found on the web). Thanks for your response and congrats on your great report since week 4 !

i would be extremely cautious about using it until more data is available especially since its purported effects on tacrolimus and cyclosporine metabolism are extreme. i am quite confident that there will be clinical trials coming down the road extremely soon.

My current dose is Prograf 3 mg AM/ Prograf 3 mg PM and Rapamune 4 mg AM. The intent is to convert me to 100% Rapamune because of the nephro-toxicity of the Prograf and my young age and because of the anti-cancer properties of Rapamune. Data, while horribly limited, has shown Rapamune's anti-cancer properties have had success against vascular tumors such as mine so EHE, in this case chronic, is part of the cancers Rapamune affects (some cancers it has no effect).

The CIs - cyclosporine and tacrolimus levels are increased significantly by the PIs - as much as 70% increased levels - I believe. I do not know of any transplant centers who have begun treatment with Invcivek or Victrelis in their liver transplant population. It appears as though we're going to have to wait until they've figured out the dosages.

I think you should go on with systemic corticosteroids and newer modes of intervention like topical tacrolimus and pimecrolimus (an immunosuppressant known as a topical immuno-modulator) are new agents. These medicines are used if patients are intolerant or unresponsive to conventional therapy. Weak tar preparations and ultraviolet B light therapy are used to increase the thickness of the stratum corneum. Keep me informed if you have any queries.

OLT recipients with HCV were randomized to receive tacrolimus+daclizumab (steroid-free) vs. tacrolimus+corticosteroids during 1999-2001 and then tacrolimus+mycophenolate mofetil (MMF)+daclizumab (steroid-free) vs. tacrolimus+MMF+corticosteroids during 2002-2005. Patients in the steroid-free arm of both periods received no steroids except for treating biopsy-proven rejection.

More frequent aFib episodes, yet found to be hypertensive on 18-hour continuous BP study in neighborhood of 160/85 average when in sinus, lower BP when in Fib. Symptomatic in that exercise tolerance is significantly less when in Fib, also with constant chest "heaviness" and mild breathlessness. Wish to control the arrhythmia which started ~ 6 mos ago and is now recurring once/week usually while asleep, and suspect that it is of parasympathetic character.

The mean birth weight and gestational age were lower in the AZP group (2,995 g vs. 3,252 g [p = .001, difference of mean: 257, 95% CI: 106.3, 408.1] and 37.8 weeks vs. 39.1 weeks [p = .001, difference of mean: 1.3, 95% CI: .5, 2.0], respectively). The AZP group had more cases of prematurity (21.4% vs. 5.2% [p < .001; OR 4.0; 95% CI: 2.0, 8.06]) and low birth weight (23% vs. 6.0% [p < .001; OR 3.81; 95% CI: 2.0, 7.2]).

I think 2 mg Prograf per day at 6 months out is a really nice dose and his Prograf blood level of 6.5 is definitely within range.

If i lower my prograf lower than 6.5 through rate i start getting discomfort right side .i am having cognitive issues on prograf that are getting very hard to live with, seems like it got alot worse after my last of three mri with contrast in two years. was hospitalized two days after last contrast exsposure white blood count went to1000, headach, fever urine got exstremly foamy, severe itching ,tighting and rashd eveloped on lower legs two weeks after.

I believe that diarrhea can cause an elevation in Prograf level. Taking Prograf with food can decrease absorption and result in a lower Prograf level. This is even more pronounced if you take it with fatty food. If Prograf doesn't upset your stomach it is best taken about 1 hour before eating - on an empty stomach. The range on my labs sheet is 4 - 16 so you are well within range.

Pentamidine (aerosol) 1x monthly, Prograf 2mg 2x daily, metroprolol tartarate 12.5mg 2x daily, magnesium oxide 400mg 2x daily, oscal, multi vitamin, vitamin d3 1000iu 1x daily. Thanks.

Blood levels of tacrolimus (Prograf) can also be equally affected for the same reason as with cyclosporine. [both drugs are calcineurin inhibitors] * omeprazole (Losec, Prilosec) * oxycodone (Oxycodone is metabolized by the cytochrome P450 system, specifically CYP3A4, of which the bergamottin flavonoid is a strong inhibitor) * hydrocodone (The hepatic cytochrome P450 enzyme CYP2D6 converts it into hydromorphone, a more potent opioid.

Found this article also that I thought might be of general interest. I appologize if this information has already been posted and/or discussed. It portrays a different picture than when the drugs were finishing trials. We new there would be many problems and hurdles to overcome once they were approved. From my standpoint, the difficulties in treating liver transplant patients was a concern. It turns out to be more of a problem of just the problem that it wasn't studied in TP patients.

I went into rejection twice in the hospital and because of this my transplant team saw it best to put me on 5mg of prograf twice a day as well as 4 mg of rapimune, which by the way was off label and i had to sign a release form for. Just within the past 2 months they lowerd my dosage of rapimune to 2mg but kept the prograf the same. My question to you is exactly how suppressed is my immune system?

I was taking 2 mg Prograf a day at 5 years out and then they tried to wean me off Prograf completely (2 mg one day then nothing the next and 2 mg the next and nothing the next and so on) and I think I had a minor component of rejection and increased my dose to 3 mg per day, I think I'd ask about the possibility of reducing the Prograf and see how that goes.

Will it come because of the fk prograf? I also fight diabetes,which I never had before the transplant.Now I feel like some junkie on pain killers.What do you think of all this? I`am worried about the future.

05mg daily of Prograf. Has anyone who had a liver transplant gotten off the Prograf completely? Inquiring minds want to know.

I am 6 years post liver transplant from genotype 3 Hep C. My doctors want to start treatment to clear the virus. I take Prograf for the liver transplant and I know Naragenin affects the Prograf levels. My question is if during treatment I also took Naragenin and my prograf levels were closely watched and adjusted for the Naragenin effects, wouldn't I have a better chance of clearing the virus.

Prograf vs tacrolimus

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