I was recently told that even a single dose of OTC or pain killers can cause a
rebound headache. I also have chronic daily headaches as well as a few migraines each week. Can the ER cocktail of Benadryl, Toradol, Zofran, Reglan, ativan ,and decadron potentially cause a rebound effect. There's some weeks, I'm in the ER 2-3 times per week . Some months, I don't go at all. At home, Ido not take anything except amlodapine and valium twice a day.