Pregabalin, is a medication used to treat epilepsy, neuropathic pain, fibromyalgia, and
generalized anxiety disorders. It is better known as Lyrica. Many physicians order opiates and Lyrica together. Methadone is a different animal. I'm not confident in saying you can safely take the two together. Your best source would be a Pharmacist. They are the true experts in medications, the side effects, interactions and so forth. They are free and you don't always have to give your name.