Pravastatin versus lovastatin
Common Questions and Answers about Pravastatin versus lovastatin
pravachol
Lipitor (atorvastatin), Lescol (fluvastatin), Mevacor (lovastatin), Altoprev (lovastatin extended-release), Livalo (pitavastatin), Pravachol (pravastatin), Crestor (rosuvastatin), and Zocor (simvastatin). Combination products include: Advicor (lovastatin/niacin extended-release), Simcor (simvastatin/niacin extended-release), and Vytorin (simvastatin/ezetimibe).
The new labels will warn patients about:
Memory loss and mental confusion.
There was a study done with 550 people in 1993, that looked at the differences in treatment with simvastatin versus pravastatin. Patients were put on a cholesterol-lowering diet and given one of the medications. After 18 weeks, patients given simvastatin had significantly lower total cholesterol, lower LDL, lower triglycerides, and higher HDL cholesterol levels than those who took pravastatin.
The interaction has also been reported in patients receiving atorvastatin, lovastatin, or simvastatin with other potent CYP450 3A4 inhibitors such as azole antifungal agents, macrolide antibiotics, HIV protease inhibitors, and nefazodone. Clinically, high levels of HMG-CoA reductase inhibitory activity in plasma may be associated with an increased risk of musculoskeletal toxicity.
Two recent trials have compared the clinical outcomes of intensive lipid lowering with atorvastatin 80 mg/day and standard lowering with pravastatin 40 mg/day. In the Pravastatin or Atorvastatin Evaluation and Infection Therapy (PROVE IT) trial, patients with acute coronary artery syndromes were enrolled, and pravastatin lowered the low-density lipoprotein (LDL)-cholesterol to 2.46 mmol/l, whereas atorvastatin lowered it to 1.60 mmol/l.
Lipitor (atorvastatin), Lescol (fluvastatin), Mevacor (lovastatin), Altoprev (lovastatin extended-release), Livalo (pitavastatin), Pravachol (pravastatin), Crestor (rosuvastatin), and Zocor (simvastatin). Combination products include: Advicor (lovastatin/niacin extended-release), Simcor (simvastatin/niacin extended-release), and Vytorin (simvastatin/ezetimibe).
Lisinopril and Carvedilol are blood pressure medications (lisinopril is an ACE inhibitor, Carvedilol is a beta blocker) and should not have any effect on your lipid profile. Both are important medications for those who have suffered a heart attack and undergone stenting. In addition to these medications, you should be on some sort of lipid medication (a "statin" such as atorvastatin, pravastatin, rosuvasatin, lovastatin, etc).
Lisinipril is $4/month and $10 for 90 days at WalMart and many other pharmacies that have the $4 precription plan. You pay out of pocket. Simvastatin isn't on that list, but lovastatin and pravastatin are, if your doctor feels like you could try substituting one of those. Metoprolol isn't on the $4/month plan, but atenolol is. Again, maybe your doctor would be okay with changing you from metoprolol to atenolol. It's worth talking to the doc about.
Lipitor (atorvastatin), Lescol (fluvastatin), Mevacor (lovastatin), Altoprev (lovastatin extended-release), Livalo (pitavastatin), Pravachol (pravastatin), Crestor (rosuvastatin), and Zocor (simvastatin). Combination products include: Advicor (lovastatin/niacin extended-release), Simcor (simvastatin/niacin extended-release), and Vytorin (simvastatin/ezetimibe).
However, since we and others have been unable to make other statins work against HBV, such as fluvastatin (Korba, unpublished results), pravastatin (Bader, unpublished results), or lovastatin (Lin et al., 2003), the reduction of mevalonate is unlikely to be the sole source of anti-HBV effect.
After recent cath my doctor changed my medication from vytorin ,have taken vytorin for 5 years, to lovastatin. I did ask for a cheaper medicine and lovastatin was what he came with. I have no problems or side effects . My question is lovastatin less effective then other of the same and if not why is it not used often. My engineering background comes out if I d not have proper data.
I've been taking Lovastatin for 2 months. For the past couple of weeks I've been experiencing aching kidneys and I'm very tired. I had blood work done today for follow up of the drug and notified the doctor that I had this problem. My body temperature is 96.8, which I realize is a bit low, but perhaps normal? Could the achiness be due to the Lovastatin? I'm quite concerned about this and have had kidney problems as a child.
//www.drugs.com/sfx/pravastatin-side-effects.html#consumer_Pravastatin
Have you discussed this with your doctor? If you take other drugs and/or supplements check with your pharmacist regarding drug interactions.
I was on 40mg of Pravastatin and now am on 80mg. Is my doc just being aggressive? Or is there another reason for the big increase? I welcome any speculations.
I am a 39 year old, female. I was put on Pravastatin about 9 weeks ago as my cholesterol had gone from 190 to 225 from the previous year. I have a family history of heart disease (my father passed away after a second heart attack at 53). I was diagnosed with hypothyroidism 2 years ago and was placed on Levoxyl (75mg) and my levels have remained normal. I went to have my cholesterol checked after taking the pravastatin for 9 weeks.
m still trying to get a clarification. Anyway, the cardiologist put me on Amlodopine and Pravastatin. Now, on a daily basis it seems, my heart rate increases and beats at 90-115 bpm (normally in the mid 70s).
At the same time, I've started on a vegetarian diet to try to lower my cholesterol. To try to make sure I get enough protein, I am using a protein drink (10-14 gr protein each). I drink 1-2 of these per day.
I was put on Pravastatin about 9 weeks ago as my cholesterol had gone from 190 to 225 from the previous year. I have a family history of heart disease (my father passed away after a second heart attack at 53). I was diagnosed with hypothyroidism 2 years ago and was placed on Levoxyl (75mg) and my levels have remained normal. I went to have my cholesterol checked after taking the pravastatin for 9 weeks.
I recently was prescripbed pravastatin and I notice a higher number when I test after a night of fasting in my Blood Glucose. Is there a posibility that could cause the rise.
Is it safe to take Levothyroxine at the same time as Pravastatin? Also, 2 months ago, I started to take my Levothyroxine at bedtime instead of in the morning as it is more convenient. and after a recent bloodtest my GP has reduced my Thyroxine to 75mcg instead of 100mcg. Could taking it at bedtime be the reason for this reduction? I will obviously ask my GP about this on my next visit to the surgery but would be grateful for any advice.
gov/pmc/articles/PMC2951407/
i didn t check the images on this article previously, fig 2 has very interesting data, it shows a decrease of hbsag to 60% by lovastatin i guess using the higest non toxic dose
lovastatin decreases only hbsag (no effect on hbvdna) by decreasing cholesterol content of hbsag infectivity of hbv is impared by fusion interference
23 versus 1.17 g ml(-1)), a smaller diameter (39 versus 48 nm), but maintained particle integrity, antigenicity and ability to bind to hepatocytes. Although addition of exogenous cholesterol and cholesterol analogues restored the physical appearance of cholesterol-depleted virions, infectivity was only regained by cholesterol add-back. Infectivity of HBV produced from cell culture in the presence of inhibitors of cholesterol-synthesis is severely impaired.
My (74 year old) father currently is taking these medications together Pravastatin Sodium 80mg, Zetia 10 mg, Isosorbide Mnonitrate 30 mg, Metoprolol tartrate 50 mg, Plavix 75 mg, Amlodipine Besylate 10 mg, Aspirin (nsaid) 81 mg low dose
The doctor told him his liver count is up 66 and the lower range is 64. Would any of these drugs or combination of these drugs make liver count increase?
I take Pravastatin, and my liver Enzymes GGT are high, but ALT and AST are in normal range, not sure why, I have heard different answers some doctors ar concern and others are not
In early September, I was prescribed a statin for the first time, 40 mg of Pravastatin, to be taken at night. After 2 weeks, I started having muscle pain/weakness in my legs but for the first time in my life had very odd heart palpatations after lying down in bed for about 10 minutes when I was first trying to sleep. I stopped taking the Pravastatin after about 1 month.
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