Pravastatin myopathy

Common Questions and Answers about Pravastatin myopathy

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Avatar f tn Clinically, high levels of HMG-CoA reductase inhibitory activity in plasma may be associated with an increased risk of musculoskeletal toxicity. Myopathy manifested as muscle pain and/or weakness associated with grossly elevated creatine kinase exceeding ten times the upper limit of normal has been reported occasionally. Rhabdomyolysis has also occurred rarely, which may be accompanied by acute renal failure secondary to myoglobinuria and may result in death.
Avatar n tn Two recent trials have compared the clinical outcomes of intensive lipid lowering with atorvastatin 80 mg/day and standard lowering with pravastatin 40 mg/day. In the Pravastatin or Atorvastatin Evaluation and Infection Therapy (PROVE IT) trial, patients with acute coronary artery syndromes were enrolled, and pravastatin lowered the low-density lipoprotein (LDL)-cholesterol to 2.46 mmol/l, whereas atorvastatin lowered it to 1.60 mmol/l.
Avatar f tn Can someone explain what, if any, evidence there for a switch from simvastatin to pravastatin? My husband's doctor said there is new evidence that simvastatin may be detrimental. Unfortunately, my husband did not quiz him further. He already has one stent in a narrow back artery but he has brought his cholesterol down considerably with the statins.
Avatar f tn //www.drugs.com/sfx/pravastatin-side-effects.html#consumer_Pravastatin Have you discussed this with your doctor? If you take other drugs and/or supplements check with your pharmacist regarding drug interactions.
Avatar n tn I was on 40mg of Pravastatin and now am on 80mg. Is my doc just being aggressive? Or is there another reason for the big increase? I welcome any speculations.
Avatar f tn I am a 39 year old, female. I was put on Pravastatin about 9 weeks ago as my cholesterol had gone from 190 to 225 from the previous year. I have a family history of heart disease (my father passed away after a second heart attack at 53). I was diagnosed with hypothyroidism 2 years ago and was placed on Levoxyl (75mg) and my levels have remained normal. I went to have my cholesterol checked after taking the pravastatin for 9 weeks.
Avatar m tn m still trying to get a clarification. Anyway, the cardiologist put me on Amlodopine and Pravastatin. Now, on a daily basis it seems, my heart rate increases and beats at 90-115 bpm (normally in the mid 70s). At the same time, I've started on a vegetarian diet to try to lower my cholesterol. To try to make sure I get enough protein, I am using a protein drink (10-14 gr protein each). I drink 1-2 of these per day.
Avatar f tn I was put on Pravastatin about 9 weeks ago as my cholesterol had gone from 190 to 225 from the previous year. I have a family history of heart disease (my father passed away after a second heart attack at 53). I was diagnosed with hypothyroidism 2 years ago and was placed on Levoxyl (75mg) and my levels have remained normal. I went to have my cholesterol checked after taking the pravastatin for 9 weeks.
Avatar n tn I recently was prescripbed pravastatin and I notice a higher number when I test after a night of fasting in my Blood Glucose. Is there a posibility that could cause the rise.
Avatar m tn Is it safe to take Levothyroxine at the same time as Pravastatin? Also, 2 months ago, I started to take my Levothyroxine at bedtime instead of in the morning as it is more convenient. and after a recent bloodtest my GP has reduced my Thyroxine to 75mcg instead of 100mcg. Could taking it at bedtime be the reason for this reduction? I will obviously ask my GP about this on my next visit to the surgery but would be grateful for any advice.
Avatar m tn When a Dr. tells you that you have Myopathy is that just the term he gives you until he narrows down his diagnosis?
1806721 tn?1554333407 My doctor has put me on generic pravastatin 20mg. A few days after I started the drug, I had a fever with flu-like symptom, and when that went away in a few days, I have been having hip/knee pains and fatigue that gets worse over the course of 2 weeks. My question is: Could these symptoms be related with pravastatin? Will these symptoms go away after a while?
Avatar f tn What is steroid myopathy? What are the symptoms? Do you have to be on prednisone for a certain lenght of time? I have been on prednisone for 12yrs. I am just wondering!!!!!!!!
Avatar n tn My (74 year old) father currently is taking these medications together Pravastatin Sodium 80mg, Zetia 10 mg, Isosorbide Mnonitrate 30 mg, Metoprolol tartrate 50 mg, Plavix 75 mg, Amlodipine Besylate 10 mg, Aspirin (nsaid) 81 mg low dose The doctor told him his liver count is up 66 and the lower range is 64. Would any of these drugs or combination of these drugs make liver count increase?
Avatar m tn I had my thyroid removed due to cancer over a decade ago and have increasingly suffered with muscle issues since then, which I now know is called myopathy. My endocrinologist at the time was unfamiliar with muscle issues related to hormones, and most seem to be unfamiliar with that. I originally tried Synthroid and Armour, which did not rk at all for me, and Levoxyl (first name brand, now generic) which I am currently on. I also need to take T3.
179856 tn?1333547362 Pfeffer et al, in the prospective pravastatin pooling project, observed that 0.5% of the patients who received 40 mg of pravastatin had ALT levels >5 times ULN and 0.2% had ALT levels >9 times ULN (Circulation 2002;105:2341–2346). Interestingly, during several statin trials, investigators observed similar incidence of increased liver enzymes in patients receiving placebo.
Avatar m tn Results What follows is a brief description of the results, limited to statins (simvastatin, atorvastatin, pravastatin) other than cerivastatin, and omitting discussion of fibrates. Rhabdomyolysis Cohort studies indicate a rate of 3.4 (1.6 to 6.5)/100,000 person years (1 in 29,000 per year) from cohort studies, supported by RCTs and notifications. Mortality with rhabdomyolysis is about 10%, giving a statin-specific death rate of about 1 in 300,000 per year.
Avatar m tn I take Pravastatin, and my liver Enzymes GGT are high, but ALT and AST are in normal range, not sure why, I have heard different answers some doctors ar concern and others are not
Avatar n tn In early September, I was prescribed a statin for the first time, 40 mg of Pravastatin, to be taken at night. After 2 weeks, I started having muscle pain/weakness in my legs but for the first time in my life had very odd heart palpatations after lying down in bed for about 10 minutes when I was first trying to sleep. I stopped taking the Pravastatin after about 1 month.
Avatar f tn Vytorin does a remarkable job of reducing your Cholesterol, much better than Zocor (Simvastatin) alone. However, Zetia doesn't seem to add anything to the picture as far as preventing heart disease is concened. But read this about Zocor: -"Zocor Users Not Warned of Risks: The FDA's June 2011 safety alert is the most serious of many warnings regarding Zocor and associated risks of myopathy and rhabdomyolysis. Zocor manufacturer Merck & Co.
Avatar n tn In mitochondrial myopathy, muscle biopsy shows abnormal stain in muscle fibres (red ragged). In addition, stains also detect absence of mitochondrial enzyme in mitochondrial myopathy. Therefore, in mitochondrial myopathy muscle biopsy can not be read normal. Hope this helps.
Avatar f tn I am 46 yrs old. I was initially diagnosed with mitochondrial myopathy about 7 yrs ago. But now, after going to a new neuro, he doesn't feel it is this. He thinks it is some kind of myopathy but not sure what kind. But I have to wonder if maybe if it isn't MS. I have muscle weakness of my upper arms and thighs and hips. Also my respiratory muscles are weak. I have tingling in my feet and arms.
Avatar m tn Further, in 2010 data from more than 2 million 30- to 84-year-old statin users from England and Wales identified increased risks of moderate or serious liver dysfunction as well, among other serious effects, including acute kidney failure, moderate or serious myopathy (muscle disease), and cataract.
11594441 tn?1419693988 d like to know if untreated long term (30 years) subclinical hyperthyroidism (MNG) can cause thyrotoxic myopathy. The doctor I saw 5 years ago said that I was just mildly hyper and that it couldn't cause my symptoms, which included climbing up the stairs on my hands and knees, difficulty rising from a chair, painful quads, stiffness, loss of shoulder-girdle and pelvic-girdle muscles and muscle cramping. The specialists I've seen haven't been able to find any other cause.