1) While it is true that certain immunosuppressive drugs, including methotrexate,
in theory might result
in increased frequency or severity of herpes recurrences,
in fact this is uncommon. It depends in part on the dose of drug; with methotrexate, this probably occurs only with the very large doses used for chemotherapy for certain cancers. The doses for ongoing conditions like rheaumatoid arthritis, psoriasis, etc are not known to actually have these effects.