plavix non responders

Are non-responders having any success with the new medications used to treat Hep C. Apparently, there is only a 32% chance or reaching SVR for this group.

If you were UND along the way but the virus later returned then you relapsed. If you never achieved UND status then you are a non-responder. I'm guessing you relapsed because current futility rules state that non responders are not supposed to stay on tx past 12 weeks. I'm so sorry to hear that you did relapse. If you were UND for a long time it at least may have given your liver a break from the relentless assault of the virus. I hope you can get rid of it the next time around.

//www.thebody.com/content/art46371.

Nearly 95% and 93% of patients in the high- and low-dose groups, respectively, achieved SVR at four and 12 weeks, while SVR at weeks 4 and 12 was achieved in 47% of low-dose ABT-450 prior non-responders. Six prior non-responders experienced viral breakthrough during treatment, and three experienced relapse following treatment. Among treatment-naive patients, IL28B genotype did not affect the likelihood of virologic response.

s a lot of alternative medicines out there, but keep in mind that NONE of them have proven efficacy. I have read of some non-responders going off treatment, getting in much better shape and trying again with SOC. How long were you treating? The other thing is to wait for the new meds. Estimates are that they will be available sometime between Summer 11 and 2012. I am wrestling with what to do now, and I have not started any treatment yet. I hope things turn around for you.

s smile at this new hope for us non-responders which is predicted to cure at least 75% of non-responders, and a time line of six months as opposed to eleven months. Look for these drugs release at mid-year. Unfortunately, the awful Ribavirin and Interferon have to be thrown into the mix, but it could be worse. We could be in line for a liver transplant. Hope is a good thing...

In 2005 had MI with occlusion of the LAD artery and had drug stent inserted and I am still on plavix. My doc has debated when to take me off the Plavix safely....what are the recent studies about this dilemma? thanks so much!

Prove 1 and 2 were for naives only. Prove3 was for non-responders. Some data is available for Prove1/2 which you can find in the Vertex press relelases. No data has yet been issued for Prove3.

What kind of stent do you have? Medicated or non-medicated? My husband had his first heart attack at age 49. He had 4 stents put in. He was on Plavix for a year - then his cardio took him off. 5 months later he had another heart attack. He is doing fine, but they are now telling us that he will probably be on Plavix for the rest of this life. That is fine with us - I would hate to worry about another clot forming. All of his stents are the medicated ones.

Excellent definition of null responders in your link: "null responders defined as non-response week 4 (<1 log drop in HCV RNA at week 4) or as non-response week 12 (<2 log drop in HCV RNA by week 12)"

anyone out there been on a trial for non-responders? I am starting one soon, but wondering if anyone else has been involved in one. Thanks for any info & good luck to all on treatment.

Just curious. Do non responders have all the side effects or no? The reason I'm asking is, I just started treatment this past friday (01/22/10) and my side effects we really not bad enough to mention. Just hope it don't mean that my body is not "responding".

Had multiple stents (4) placed four (4) years ago, two in LAD with no side effects and good nuclear and stress test results over this period. Am currently taking Plavix/Aspirin/Coreg/Altace. Need arthroscopic repair on knee but concerned over cessating of Plavix. One cardiologist recommended ending Plavix entirely, second (same practice) would rather wait for a large study about to be completed. Suggestions?

About 4 years ago during a routine Echo stress we discovered I had blockage in the LAD and diagonal. I had drug-eluting stents put in and I have been on 75MG Plavix, 50MG Toprol XL, 81mg aspirin, and 80mg simvastatin ever since. I never had any symptoms and I still have none. Just wondering about a professional opinion about being on these medications for life as well as the efficacy of generic drugs. I obviously am also concerned about possible restenosis in the stents.

On the side issue of what type of responder you were... "i only had a 1 log drop" If you only had a 1 log drop at week 12 you were a "null-responder". A "non responder" is someone who during treatment never became undetectable. Non responders are broken down into 2 subgroups "null responders" and "partial responders".

Vertex hopefully will get approval for their new drug to treat non-responders first. Even so if you watch your diet with no alcohol you should be ok for the regular approval in the next few years.

I have three drug eluting stents in the LAD, two non-drug eluting stents and three drug eluting stents in my RCA. I stayed on Plavix for 1.5 years after the last stent, and been off Plavix for over a year with no restinosis. I do exercise daily, take Vytorin, 81mg aspirin, and follow a healthy heart diet very carefully. So far, no problems with restenosis, but believe me, I think about it every day.

Does anyone know the svr rate on viekira for 1a non-responders? Insurance wants me to try viekira.

My mother took Plavix and I notice the same effect on my mother who is 85 years old. When I brought this to her attention she agreed she felt better and was more cognisent without it. She decided she wanted her clarity more than the effect of the drug and has been off it for two years. She continues to take Asperin daily. She had a double stint placement four years ago.

t find the link to the slide set about slow and non responders, but it is consistent with what they told you. Of course they are really saying that based on observation the probability of SVR with your age and VL stinks, really stinks. you had a 1 log drop and that sadly is not very much. I know how you feel; I had a 1.3 log drop the first time through.

Thanks for that post, very succinct and very helpful. I was a null or non-responder last time, but they haven't differentiated so I'm going to fillow that up thanks to this post. Back in 2004 they made me go the whole 24 weeks (I'm a Gt3a) despite not achieving an EVR at Week 12, pretty rough. I'm in re treatment now and got a forced RVR (PCR neg at 4 weeks) from a PI trial and I'm trying to push to treat for longer given my history.

Relapse means that HCV became—and remained—undetectable during treatment, but reappeared within weeks to months after finishing it. Since revalation was not undetected at the end of 12 weeks, didn't finish treatment. Revalation had at least a 2 log drop and then an increase in VL. That's why I think would be considered a partial responder, making chances for SVR 59% on triple. A doctor could answer this for certain.

Plavix non responders

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