The clinically important adverse reactions observed in trials comparing Plavix
plus aspirin to placebo plus aspirin and
trials comparing Plavix
alone to aspirin alone are discussed be
In CURE, Plavix use with aspirin was associated with an increase in major bleeding
(primarily gastrointestinal and at puncture sites) compared to placebo with aspirin. The incidence of intracranial hemorrhage (0.1%) and fatal bleeding
(0.2%) were the same in both groups.