pioglitazone and osteoporosis

To test the effectiveness of pioglitazone and vitamin E, Sanyal and colleagues at 11 other medical facilities identified 247 people who had severe fatty liver disease. None of the volunteers drank alcohol excessively or was diabetic, but all were overweight or obese. Their average age was in the mid-40s. The researchers randomly assigned participants to one of three treatments — vitamin E, pioglitazone or a placebo capsule — taken daily for nearly two years.

Study Confirms Benefits of Vitamin E in Nonalcoholic Steatohepatitis Megan Brooks May 4, 2010 — Supplementation with the natural form of vitamin E (800 IU/day) has beneficial effects in patients with nonalcoholic steatohepatitis (NASH), but pioglitazone's benefits are less clear, according to the latest findings from the Pioglitazone vs Vitamin E vs Placebo for the Treatment of Nondiabetic Patients with Nonalcoholic Steatohepatitis (PIVENS) trial, reported online April 28 in the New England

Thank You very much for your reply, As I mentioned above, she was given new medicined once she experienced high blood sugar level few weeks back. She was given Metformin (850 mg) and Pioglitazone (30Mg per day). Once she started experiencing low blood sugar level, the doctor stopped giving Pioglitazone and asked to continue Metformin with few other medicines and the my mother was told that she experiencing such low levels of sugar due to Pioglitazone.

For women who are unresponsive to clomiphene,the oral hypoglycemic agents like metformin could be of little help, or pioglitazone, may bring resumption of regular cycles and ovulation. These agents reduce the hyperinsulinemia and hyperandrogenemia in PCOS. These are actually medically prescribed medicines for PCOS.As this syndrome is very common in women the case is often individualised and treatment option will be processed and prescribed.Fell free to talk to your Doc.

Osteoporosis is most common in women after menopause, when it is called postmenopausal osteoporosis, but may also develop in men, and may occur in anyone in the presence of particular hormonal disorders and other chronic diseases or as a result of medications, specifically glucocorticoids, when the disease is called steroid- or glucocorticoid-induced osteoporosis.

Osteoporosis is a common condition where the bone becomes thin and fragile, creating an increased risk of fracture. Osteoporosis is usually painless until a fraction takes place, and osteoporosis is a major contributing factor to bone fracture, including hip fractures, which are more common as people age. There are almost 2 million hip fractures annually around the world. While in the U.S.

Also, other autoimmune diseases (celiac disease) cause malabsorbtion and therefore can contribute to osteoporosis. Many people have multiple autoimmune diseases. HTH.

among the two drugs Pioglitazone (Actos) has less sides and also active against HCC but i didn t find a study on its activity against hbsag and hbvdna http://www.ncbi.nlm.nih.

I just googled ribavirin and osteoporosis, and there does seem to some connection, so will try to print out some articles for new doc, and will take all my hcv tx info with me too.

I take Synthroid for hypothyroidism, and I was diagnosed with osteoporosis, I have tried several times to take calcium supplements within the guidelines when taking Synthroid, (more than 4 hours before or after taking med), and I become almost immediately exhausted, and sleep for 8-12 hours. I take only about 250 mgs of calcium, and vitamin D as well.

My TSH is now and has been for some time, at 0.01, my FT's are now slightly < mid range; and my doctors keep saying that it's going to cause osteoporosis; however, I've done some research and found that not to be true. In fact, I just posted for information about that a week or so ago and was given a couple of good sites. Here's the post: http://www.medhelp.

agreed that the '08 metformin study did not make a strong case for adding metformin in all patients, however you might also want to look at a recent Khattab'10 study that looked at adding pioglitazone in geno 4s with HOMA1 gt 2. http://www.ncbi.nlm.nih.gov/pubmed/19919569 They measured across-the-board improvement in SVR rates 60% vs 39% significant at 0.04. Geno 4s seem to be particularly susceptible to IR-related effects so this may not generalize.

My doctor told me that I have Osteoporosis and wants me to try Forteo an injection for two years. Has anyone tried this drug and what were your side effects, if any. I don't want to make my stomach problems worse than there already are.

I have started mega doses of supplements and calcium and D and excercise and I want someone to tell me that that has worked for them. Most comments I get is to take the drug because it's more effective. I can't believe everyone is taking bisphosphonates or other drugs like that. Please let me hear from you if you see this!,,, Thanks, and hope you are doing well!

I just had my frist Bone scan and the office called me and said I had osteoporosis and that they called in RX for Atelvia.. I picked up the RX and was reading the information and I am concerned about the side effect of this medication. Is this the only way to help with osteoporosis? Is there anything elso another way?

Osteoporosis is the thinning of bone tissue and loss of bone density over time. If you do not get enough calcium, or if your body does not absorb enough calcium from the diet, bone production and bone tissues may suffer. As you age, calcium and phosphate may be reabsorbed back into the body from the bones, which makes the bone tissue weaker. And this happens with the bones of your entire body.

I expect she is Anxious about it all aswell does she get out and is she as busy as she can be as she has a lot of pain ,it could make her feel very fedup, and that makes it worse.Does she have exercises to do for the Osteoporosis, I think they reccomend some to strenghthen her . There are a few books on the Market she can read .I hope you both do better soon, sounds like she needs some answers and she needs to demand them.

Hello Dear, Connective tissue diseases are chronic inflammatory autoimmune disorders which can affect all connective tissues, i.e. joints, skin, muscles and blood vessels, and therefore have multiple effects on many different organs throughout the body. Although the commonest one is rheumatoid arthritis. Osteoporesis is not a connective tissue disorder,it may accompany a connective tissue disor Refer http://www.arc.org.uk/arthinfo/medpubs/6529/6529.aspder.

Hello Dear, Connective tissue diseases are chronic inflammatory autoimmune disorders which can affect all connective tissues, i.e. joints, skin, muscles and blood vessels, and therefore have multiple effects on many different organs throughout the body. Although the commonest one is rheumatoid arthritis. Osteoporesis is not a connective tissue disorder,it may accompany a connective tissue disor Refer http://www.arc.org.uk/arthinfo/medpubs/6529/6529.aspder.

0 and TT4 around 4.5). Each SAT occurance, my iodine uptake was initially zero and TPO and thyroglobulin antibodies negative. I was diagnosed with osteoporosis 2 years ago with Dexascan results having Z-scores slightly below -2.5. Recently I have been experiencing vague symptoms (fatigue, dry skin and hair, brain fog, etc.) that I attributed to recent menopause but my thyroid tests revealed the following: TSH = 4.24 (0.34-5.60) FT4 = 0.64 (0.62-1.12) TT4 = 3.9 (4.5-12.

My doctor had a bone density scan done and it showed early signs of osteopenia, not unusual for my age and for being postmenepausal. One year later, I was diagnosed with MS. Started on Copaxon, and seem to be keeping it at bay. Now, at 52, I suffered a pathological fracture of my sacrum, lifting a patient during my occupation as a paramedic. I should also mention that I have grade B spondilitis in my back at L5 and S1.

Hi im 29 and was diagnosed with Osteoporosis in the spine when i was 27, also have the mild form in my hips as well. Well i've just found out (after going through fertillity treatments) that i am 4 weeks pregnant. Im starting to worry about how my back will cope with carring a child, I've had a painfull back since way before the diagnosis, constently need regular physio to reduce the knots in my lower back/pelvis area.

He said I probably have osteoporosis. I have to have another one done in a month to see if the prevlimid worked and I am worried about the same thing happening. Where else besides the hip can they do it?

Are you on med for your osteoporosis? I've had osteopenia for quite a few years and have been on a dosage of calcium and have actually begun to turn it around and rebuild some of the bone I had lost. I'm not sure that can happen with full blown osteoporosis or not, but it might be worth looking into.

I have been diagnosed with osteoporosis and have noticed that recently I have a lot of pain in my teeth and jaw. This has prompted me to wonder if osteoporosis affects the teeth in general as they are inbedded in bone? And how so?

Pioglitazone and osteoporosis

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