phenytoin warfarin interaction

To date there have been no reports of an important interaction in humans between warfarin and clopidogrel. Nonetheless, because warfarin increases the risk of bleeding, blood tests to measure the degree to which the blood is anti-coagulated or thinned (prothrombin time; INR) may be ordered to assess the degree of blood-thinning when warfarin and clopidogrel are used together.

) At high concentrations in vitro, clopidogrel inhibits P450 (C). Accordingly, Plavix may interfere with the metabolism of phenytoin, tamoxifen, tolbutamide, warfarin, torsemide, fluvastatin, and many non-steroidal anti-inflammatory agents, but there are no data with which to predict the magnitude of these interactions. Caution should be used when any of these drugs is co administered with Plavix.

A 77-year-old woman who developed a 2-fold increase in INR while receiving APAP with concomitant acenocoumarol (8), and a 74-year-old man experienced a 3-fold increase in INR when APAP was added to his stable warfarin regimen (6). Fluindione has also been implicated in this interaction (9). In a prospective, randomized, double-blind, placebo-controlled trial 36 patients received either APAP 2 g daily, 4 g daily, or placebo for 4 weeks.

You should contact your caregiver for advice regarding your medication as they would have your medical history, general health, etc. There is a noted drug interaction with Viagra and warfarin in certain patients. In patients who have pulmonary hypertension, there is an increased risk of bleeding when taking these medications together, etc.. Thanks for your question, take care.

Pradaxa is taken twice a day, shorter life in the body and is cleared from the body quicker than coumadin (warfarin). With warfarin, Vitamin K is used to reverse overanticoagulation in patients, there is no antidote for Pradaxa. Warfarin a lot cheaper than Pradaxa. Good luck with your ablation. Hope you do well on Pradaxa! Best wishes!!

What thyroid medication are you taking? Get a TSH, a Free T4, and a Free T3 run, and see where your hormones really are. You may be high on your Free T3.

Great site! I've bookmarked it for future reference. Thanks for the information.

I wanted to understand if he has to be cautious while using other drugs and what interaction Acitrom has with other drugs. He has been on Acitrom for a week now and has to use it for life. Also, could you please provide me with any website that gives all possible information on Acitrom? I searched through Google but wasnt successful in finding the relevant information. I found this website...Your quick reply will be highly appreciated.

I am a long time user of Warfarin anticoagulant because of my AFib condition. The generic Warfarin cost about $10 (Walmart for example) for a 90 supply. My wife recently had major surgery to remove cancerous organs and is required to take a daily anticoagulant for 30 days. In her case it is injected by syringe and each Cost about $50, throw away devices. That a whopping $1,500 for 30 days.

For widespread or stubborn infections, itraconazole tablets have shown good results in curative aspects, but avoid its interaction with other drugs like antacids, astemizole, phenytoin and rifampicin. Most patient think the treatment has not worked if their pale patches do not disappear straight away. Please remember that the patches will take a long time to disappear and the treatment does not equate with disappearance.

No problem with seizure meds but began having terrible oder issues ,everything smells horrible - skin, food , lotions, shampoos etc. Could this be interaction with these meds . ?

In a small study, phenytoin-induced seizures occurred most often in patients with serum phenytoin concentrations of 50 mcg/ml or higher.[393] Peripheral neuropathy, usually occurring weeks to months after drug initiation, has also been reported in patients receiving phenytoin. A single case report describes the onset of neuropathy within a few hours of drug administration.[9780] Adverse GI effects of phenytoin therapy include nausea/vomiting, constipation, abdominal pain, and anorexia.

Other medications that increase the risk for anemia are certain antibiotics, some antiseizure medications (phenytoin), immunosuppressive drugs (methotrexate, azathioprine), antiarrhythmic drugs (procainamide, quinidine), and anti-clotting drugs (aspirin, warfarin, heparin).

This can result in either physical or mental changes to to what is your normal modus operandi. It could also be a drug interaction - bladderwrack is a mild anticoagulant, & could enhance the effects of meds like asprin & warfarin. the body is sooooo complex, I seriously wish I had an instruction manual.

Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..." It however says that initiation of Folic acid and phenytoin together is beneficial. Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.

Combining fluoxetine or paroxetine with phenytoin can also lead to increased phenytoin side effects and reduce blood levels of paroxetine. You really need to discuss the potential drug interactions with your own doctor.

levothyroxine and insulin isophane (Moderate Drug-Drug) MONITOR: The efficacy of oral hypoglycemic agents and insulin may be diminished by certain drugs, including thiazides and other diuretics, corticosteroids, estrogens, progestins, thyroid hormones, human growth hormone, phenothiazines, atypical antipsychotics, sympathomimetic amines, protease inhibitors, phenytoin, clozapine, megestrol, danazol, isoniazid, asparaginase, pegaspargase, diazoxide, temsirolimus, as well as pharmacologic dosag

For widespread or stubborn infections, itraconazole tablets have shown good results in curative aspects, but avoid its interaction with other drugs like antacids, astemizole, phenytoin and rifampicin. Most patient think the treatment has not worked if their pale patches do not disappear straight away. They should be warned in advance that the patches will take a long time to disappear and the treatment does not equate with disappearance.

You should tell your doctor if you experience any of these symptoms while taking phenytoin, so that your blood level of phenytoin can be measured and your dose reduced if necessary. " Also, he has had a major surgery, and will need time to recover. However, any changes need to be reported to the doctor.

Moban® brand of molindone hydrochloride contains calcium ions which interfere with the absorption of phenytoin. Ingestion times of phenytoin and antacid preparations containing calcium should be staggered in patients with low serum phenytoin levels to prevent absorption problems”. Taken from http://www.rxlist.com/cgi/generic/phenyt_od.htm Our population is divided into 4 type of metabolizers ranging from rapid to slow metabolizers depending upon the speed of elimination of drug from body.

Phenytoin warfarin interaction

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