Phenytoin therapeutic levels

Common Questions and Answers about Phenytoin therapeutic levels

dilantin

Avatar n tn Hi there. Since your frequency of seizures has increased you need to have a fresh evaluation of your neurological function clinically, with a recent MRI brain and an EEG. The antiepileptic drugs need to be checked for a dosage modulation, assessment of adverse effects due to chronic usage over years like megaloblastic anemia, gingival hypertrophu and osteomalacia with phenytoin. Take care.
Avatar n tn Hi, is he on some other drugs too because other drugs might decrease the level of phenytoin by enhancing its metabolism via induction of enzymes and can lead to drug drug interction. “Drugs which may decrease phenytoin levels include: carbamazepine, chronic alcohol abuse, reserpine, and sucralfate. Moban® brand of molindone hydrochloride contains calcium ions which interfere with the absorption of phenytoin.
Avatar m tn In a small study, phenytoin-induced seizures occurred most often in patients with serum phenytoin concentrations of 50 mcg/ml or higher.[393] Peripheral neuropathy, usually occurring weeks to months after drug initiation, has also been reported in patients receiving phenytoin. A single case report describes the onset of neuropathy within a few hours of drug administration.[9780] Adverse GI effects of phenytoin therapy include nausea/vomiting, constipation, abdominal pain, and anorexia.
Avatar n tn Combining fluoxetine or paroxetine with phenytoin can also lead to increased phenytoin side effects and reduce blood levels of paroxetine. You really need to discuss the potential drug interactions with your own doctor.
Avatar f tn Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..." It however says that initiation of Folic acid and phenytoin together is beneficial. Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.
Avatar m tn An occasional one or two drink may be fine but moderate or large amount can cause significant increases in blood levels of phenytoin due to induction of hepatic enzymes. Whereas if you are a chronic alcoholic, the phenytoin levels may be lower than expected and can cause seizures. I suggest you consult with your neurologist in this regard. Hope this information helps. Take care.
Avatar f tn There may be wide interpatient variability in phenytoin serum levels with equivalent dosages. Patients with unusually low levels may be noncompliant or hypermetabolizers of phenytoin.
Avatar f tn I was then lowered to 200mg which I could handle quite well. My levels were checked in Feb.08 and the levels were low at 29, my Dr. raised the dose to 250mg wich moved my levels to 55. which she said was good. In a short time of being on that I started to get the same side affects as on the 300mg. My Dr. told me to go back to the 200mg and she would have to talk to my Neurologist, I just had blood work done again and my phenytoin level come back at 2. How is that possible?
767237 tn?1332640177 I use to take lexapro and clonazepam for the last 6 years. Pdoc said I should've never been on the lexapro because it was making me rapid cyscle, Now I take 25 mg of Lamictal (can't go up because pdoc is saying that it's making me manic), 50 mg of Seroquel, 900mg of Lithium and 1 mg of clonazapam. I actually use to have to take 3 mg of clonaz but I think the seroquel is making me not need it as much.
Avatar m tn The efficacy of oral hypoglycemic agents and insulin may be diminished by certain drugs, including thiazides and other diuretics, corticosteroids, estrogens, progestins, thyroid hormones, human growth hormone, phenothiazines, atypical antipsychotics, sympathomimetic amines, protease inhibitors, phenytoin, clozapine, megestrol, danazol, isoniazid, asparaginase, pegaspargase, diazoxide, temsirolimus, as well as pharmacologic dosages of nicotinic acid and adrenocorticotropic agents.
Avatar n tn The efficacy of oral hypoglycemic agents and insulin may be diminished by certain drugs, including thiazides and other diuretics, corticosteroids, estrogens, progestins, thyroid hormones, human growth hormone, gonadotropin-releasing hormone agonists, phenothiazines, atypical antipsychotics, sympathomimetic amines, protease inhibitors, phenytoin, megestrol, danazol, isoniazid, asparaginase, pegaspargase, diazoxide, temsirolimus, sucralfate oral suspension, as well as pharmacologic dosages of nic
Avatar f tn Does prednisone effect dilantin and lamictal levels? I've been on dilantin and lamictal for over 5 years for seizures. I'm being tested for autoimmune hepatitis, I just had a liver biopsy. I don't want to take a chance on having a seizure.
Avatar m tn I believe that the benefits pf statins outweigh the risks and have altered my eating lifestyle so to nearly exclude carbohydrates. This has enabled me to continue statin regime while keeping my fasting blood glucose levels at acceptaptable unmedicated levels. My wife on the other hand continues to take Metformin while on the statin drug.
1291453 tn?1272143404 You should tell your doctor if you experience any of these symptoms while taking phenytoin, so that your blood level of phenytoin can be measured and your dose reduced if necessary. " Also, he has had a major surgery, and will need time to recover. However, any changes need to be reported to the doctor.
Avatar f tn My 18 year old daughter was almost totally resistant to the repeated rounds of SoluMedrol (5 days each time), so in the last two months, she has been hospitalized twice for PLEX (also called TPE, or Therapeutic Plasma Exchange). Each time, a Shiley catheter was implanted in her right internal jugular vein (neck), and she received 7 every other day Plasma Exchange. The first round in October, she had spectacular recovery, but that only lasted for 2.5 weeks.
Avatar f tn I was diagnosed with lupus anticoagulant blood disorder. I have a leg full of clots that won't break up and go away. They have been treated for 3 years with warfarin, lovenox and cumadin. All to no avail. My gp doctor doesn't seem to have the knack to getting the INR levels stable. I've been at levels of 6 and 6.5 many times leading to ER transfusions. Last week it was 1.1 I'm worried because the symptoms are so much worse lately.
Avatar n tn Thank you for your question, you are relatively fine with Phenytoin and the seizure episodes in a form of lack of speech are the residue of a generalized type seizure. I don’t have a full description of your consciousness during the lack of speech episodes to decide whether this start is a partial epilepsy which can continue in a generalized or it is a generalized one from the first moment..
Avatar m tn Sure enough, I had a full fledged grand mal for the first time in 18 years. My blood levels showed I was low (well below the desired 10 to 20). Can anyone tell me why the generic works different than the brand name? I've heard they use different bonding agents for the capsules as one possibility.
Avatar f tn During those times I had not yet been diagnosed and was able to go back to life like normal, however after the diagnosis and being on phenytoin and switching to oxcarbazepine i am feeling awful. Dizzy, nauseated, moody, extremely tired, severe headaches that come and go. All i get from my Neurologist is these are side effects that will eventually go away. Because i never know when these symptoms will come on too strong I have missed a lot of days at work during my probation period.
2067461 tn?1331216830 It means that zoloft absorption and its therapeutic levels in the blood will be achieved for kidney disease patients. It will act due to the adequate therapeutic levels. But since there is a problem with excretion, the dosage may need to be adjusted to lower levels. Hope this helped and do keep us posted.
Avatar f tn t come back as a surprise to her considering after the blood work came back my LFTs came back elevated so my alt and ast levels as well as albumin levels were high. I also found out I am pre diabetic and my platelets had dropped from 247 to 177 in a month. I am not sure how I could be pre diabetic considering I lift weights and do cardio six days a week along with eating healthy but my spleen and liver were enlarged based on physical examination.
Avatar n tn * phenytoin (Dilantin), * valproic acid (Depakote, Depakote ER, Depakene, Depacon), * carbamazepine (Tegretol, Tegretol XR, Equertro), and * phenobarbital Antibiotics such as: * tetracyclines, [for example, tetracycline (Achromycin)] * sulfonamides, * isoniazid (INH) (Nydrazid, Laniazid) * sulfamethoxazole (Gantanol), * trimethoprim (Trimpex; Proloprim, Primsol) * nitrofurantoin (Macrodantin; Furadantin; Macrobid), * fluconazole (Diflucan