pegasys pi

I treated in 2008 with a different doctor, and I weighed the same 115 lbs, and took 1000 mg of riba per day (with pegasys, no PI). I treated for 16 weeks (when I reached UND) and I did not take any rescue drugs (my hgb went from 14.5 pre tx, to 12.0, 10.4, 10.0 and at wk 12 to 9.9 and at wk 16 to 9.8.) - I stopped tx to wait for new PI . My current hgb is 13.5. How can these new doctors state that I should only be taking 800 mg of riba because I weigh 115 lbs?! This is very upsetting to me.

i am currently into my 6th week of treatment w pegasys and copegus and my dr wants 2 add victrella as soon as he can get my insurance 2 approve. i was wondering if any1 has already started their treatment w victrella as well as the pegasys and copegus so i may get a bit of insight as 2 what i may expect if they do approve me.

- Willy ---------------------------------------- More than 80% of Hepatitis C Patients Treated in Study C208 Achieved an SVR with Telaprevir-Based Regimens * 83% SVR achieved with twice-daily regimen of telaprevir dosed with PEGASYS and ribavirin * Results highlight the use of response-guided therapy in managing treatment outcomes * Similar safety and tolerability observed between telaprevir-based regimens dosed either twice daily or three times daily BOSTON, Oct 31, 2009 (BUSINES

I am Genotype 2 on Pegasys and ribovarin. My doc says I have a 90% cure rate in 6 months. It costs me 80.00 a month.

your dr. is being pessimistic, but not by that much. Take a look at the SVR prediction algorithm http://www.medhelp.org/photos/show/235555?type=user_journals and accompanying paper cited here http://www.medhelp.org/user_journals/show/235555/SVR-forecasting As things stand you're in team yellow, but in the subgroup with the darker hatches, those still with detectable vl at w12, with svr odds of about 20%. You've got plenty of company - about 17% of patients fall into that group.

Well, my NP actually suggested I should wait for telapravir and bocepravir. However, considering my goals in life and where I would like to be in the next year, she suggested starting riba/pegasys. She mentioned she has treated many patients my age group (patient in 20's) and had successful outcomes. I guess it really depends on what the patient wants, and if the hepatologist/ NP feels comfortable considering certain factors in the patient's life.

Someone once posted a helpful video site on how to inject pegasys and I was wondering it there is any information on how to inject procrit. My last two hgb blood test results were 9.7 and 9.4 , so my doctor is going to order procrit for me. I am going to get procrit 40,000 units per ml per week. Is that the dose that everyone else is doing? Do you have to mix the solution or measure it out to inject ? My mind is a bit foggy these days....

i'm in a clinical trial with peg/riba and a PI (not sure if i'm getting a placebo or the real PI). i'm in my 7th week and so far i'm still doing my cardio classes 3x a week. i don't always last the whole hour but it's better than not going. i've become a little anemic for now. good luck with your tx and may your sides be minimal.

My previous experience was an unsuccessful initial tryst with Pegasys. After relapse, my GI doc insisted I take a referral to a large hepatology transplant and research clinic. As a relapser, I assumed I was going to start again with Infergen, which is FDA labeled for this purpose. The new doc said that while he’d certainly prescribe Infergen, his experience was such that it wasn’t that effective. Without delving in to the mechanics of the meds, he suggested I try switching to Pegintron.

Thanks and I will study that material. I suppose I will take the Pegasys whichever anti-viral I use. But I wonder as I was a "partial responder" to Pegasys before (no virus @12 weeks, 212,000VL@24 week and no virus@48 weeks) I'm wondering if I might be better off this time with the Peg-intron. Guess I might flip a coin. BTW, I'm 70 miles south of Tampa in Arcadia. Guess I need to add that to my profile.

I treated in 2008 and I took 1000 mg ribavirin a day and 180 ug of pegasys injection once per week – I reached UND at week 16, but stopped tx because I did not want to treat for 72 wks with low odds and I decided to wait for new PI. Now my (new) doctor is going to treat me with PI and wants to only give me 800 mg of ribavirin a day (I will be taking pegasys and incivek).

I'm wondering if it was Spectda that commented on this earlier? It could have been Willing but I don't think so. I've been reading the Merck information online for Vic.but can't find my answer as of yet. NY girl- You are right, I need one of the "smart guys" I am only smart enough to think up the questions...and I often don't really understand the answers when they arrive.

Hi, I'm expecting to begin tx in about a month. I'm stage 3/6, genotype 1a, vl around 1.5 million. I'm also HIV positive which is under control with meds (CD4 550-600, vl 101). I know this somewhat reduces my odds for achieving SVR, can anyone tell me whether coinfection is likely to have any effect on the severity of the side effects? I know I'll be taking 180 mg Pegasys, I don't know how much riba I'll be getting yet.

When I started treatment my Hemaglobin went down to low so I am on the Pegasys (Ignore spelling) Victruelis and Ribavarin now they have me on the Rib 3 in the morning and thats it the Victrulis 3 times a day. This week I dropped down to 9.7 I think was my number with out going back to look I was at 10.2 so If I keep dropping I am afraid of what may happen I have come this far! If I should eat something or take something I will! I dont understand why I go back and fourth so much.

NCT01331850 accepts those who have previously taken an HCV protease inhibitor? The inclusion/exclusion criteria does not mention this, only that previous treatment failures are ok as long as treatment ended more than 12 weeks before. I assume this means SOC. ???

It would be better to wait for the specialists that to go to some GI guy who has never treated with the PI on board and doesn’t have the information, training and staff to really deal with the issues that may emerge. If you want to be safe in treating, wait your turn patiently for a specialist and the reward will be that those professionals will be able to help you more and keep you safe from harm.

terry: thanks! all: I was comparing the boceprevir phase II http://clinicaltrials.gov/ct2/show/NCT00423670 relative to the Vertex phaseIII: http://clinicaltrials.gov/ct2/show/NCT00627926? and Roche's phase II for R1626 http://clinicaltrials.gov/ct2/show/NCT00517439 Some of the following points surfaced. Any thoughts. explanations, corrections?

of the PI twice daily for the first 4 weeks along with pegasys and Copegus (SOC). I then continued with just the pegasys and copegus for an additional 44 weeks. I was UND by week 4 (6 log drop). Week 48 (EOT) test results "HCV RNA not detected" (Taqman 2.0) RBC, WBC, (and all associated with them) were low. All other tests were Normal. Next test in 3 months, then 6 months. If all is good That means SVR baby!!!

The first time (2008) was a trial with Roche 1626 polymerase inhibitor, Pegasys and Ribavarin. I was UND between 7 or 8 weeks, relapsed 6 weeks after being pulled from tx at 43 of 48 weeks as the trial drug was too harsh on my system. Back then they refused to give me rescue drugs so I had no choice. I have diabetes which may have contributed to my relapse, during tx my sugar was so low I stopped checking it, DUH!

I think you should be okay. I don't think that they would compromise the trial, there is much to much involved for them to mess it up. The shot has a longer half life than 7 days, especially if you are on Pegasys. I can't remember how many days, but you should have enough Peg in your body to keep the level up. Also since you are on a PI on top of this. I would say not to worry.

You did not state which PI you will be using. Here is what I found for Incivek or Victrelis in combo with Pegasys, Ribavirin and Simvastatin. Both PIs are contraindicated.

Common Questions and Answers about Pegasys pi

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