The most common serious adverse event (3% in CHC <span style = 'background-color: #dae8f4'>and</span>
5% in CHC/HIV) was bacterial infection (e.g., <span style = 'background-color: #dae8f4'>sepsis</span>
, osteomyelitis, endocarditis, pyelonephritis, pneumonia). Other serious adverse reactions occurred at a frequency of <1% and
included: suicide, suicidal ideation, psychosis, aggression, anxiety, drug abuse and
drug overdose, angina, hepatic dysfunction, fatty liver
, cholangitis, arrhythmia, diabetes mellitus, autoimmune phenomena (e.g.