Paliperidone solubility

Common Questions and Answers about Paliperidone solubility

invega

Avatar n tn Finally, since about year he began giving him INVEGA (paliperidone) injection 50 mg which he is fine with it. The problem is that he has become sperm non-existent as he told me. Will it disappear in case he stop taking the injection after a long period of use???? I am very confused, particularly as he wants to get married and be a father.
Avatar n tn For the past couple years I have been on paliperidone which is generic for invega which I know can cause extreme weight gain. Couple that with my increasingly poor eating habits, I definitely ballooned in weight. For about the past two months I have gone on a heavy calorie restriction that I know is deemed to be unsafe and unhealthy. I want to say now that with respect, I would prefer you focus on my question at hand and not about telling me to eat more food than I currently do. Thanks.
Avatar m tn Methadone has a slow metabolism and very high fat solubility, making it longer lasting than morphine-based drugs. Methadone has a typical elimination half-life of 15 to 60 hours with an average of i would say about 22. However, metabolism rates vary greatly between individuals, up to a factor of 100 ranging from as few as 4 hours to as many as 130 hours, or even 190 hours. So it's hard to say.
Avatar m tn The water solubility of bilirubin allows the bilirubin to be excreted into bile. (Bile then is used to digest fats.) Total bilirubin, if I remember correctly, is the conjugated hemoglobin, since there is also another portion that is not conjugated. What the elevated total bilirubin means at this point is 'something' is going on, but you may need more information before your doc can determine the cause.
Avatar m tn Well will wonders never cease? Are we surprised about the information? I guess they had to spend money on something after they couldn't buy donuts for doctors offices anymore.
Avatar m tn The main requirements for them are (1) high IFN-inducing activity, (2) absence of side effects, (3) wide spectrum of antimicrobial activity, (4) broad therapeutic security and, (5) good solubility in water and biologic liquids. IFN inducers stimulate IFN production in different cells and organs, and that determines the strategy for their application. Amixin (OOO "Lancepharm," Moscow, Russia) induces IFN-?/? production mostly in T cells. Cycloferon (NTFF "Polysan," St.
Avatar n tn However, factors that can affect absorption include oral pH, salivary enzymes, lipid solubility, and molecular weight (molecules may be too large to pass through the mucous membranes). A sublingual product, specifically created to ensure effective absorption, is recommended.
Avatar n tn (By the way, although losartan is currently being researched in Johns Hopkins clinical trials, other ARBs such as telmisartan are probably most effective given their increased lipid solubility and thus increased tissue penetration.) I strongly encourage you to visit www.marfanlife.net and find the very lengthy thread titled "Losartan" or something to that effect. Probably some of the most important reading of your life.
Avatar m tn the brain is affected quickly as alcohol will cross what is called the blood-brain barrier due to its solubility. this can compromise involuntary actions such as heartbeat, breathing and gag reflex. organs such as the liver and pancreas can suffer tissue destruction resulting in everything from lowered function and scarring to complete organ failure. for diagnosing existing damage, your doctor can order bloodwork including a liver panel to check things like enzyme levels.
Avatar n tn Insulin glargine is a human insulin analog that has been designed to have low aqueous solubility at neutral pH. At pH 4, as in the LANTUS injection solution, it is completely soluble. After injection into the subcutaneous tissue, the acidic solution is neutralized, leading to formation of microprecipitates from which small amounts of insulin glargine are slowly released, resulting in a relatively constant concentration/time profile over 24 hours with no pronounced peak.
Avatar m tn Hi & Welcome! A BB King fan, eh? Well, Congratulations on your 3 Days off Subs! While the majority of people I've known (including myself) to come off Bupe experience w/d's b/w 24 & 48 hours , some have reported that it 'ramps up'/intensifies between 72 - 96 hrs. Have you had any kind of opiate habit before? If not, it's just possible that you might experience milder w/d's than someone w/ a longer history.
Avatar m tn Because of its small size, Ru can be easily conjugated to any protein ligand using standard chemistries without affecting immunoreactivity or solubility of the protein. In a typical agent-detection assay, a sample is added to a mixture of capture antibody-coated paramagnetic beads and a Ru-conjugated detector antibody. After a short incubation period, the analyzer draws the sample into the flow cell, captures and washes the magnetic beads, and measures the electrochemiluminescent signal.
Avatar m tn t really have anything to do with fat solubility. Sometimes this happens easily, sometimes not, sometimes never for the really unlucky, but that's not common, but it is a good reason not to fool around with this. Better safe than sorry.
4031436 tn?1349148172 Hi Mylah. Some notable points to consider: The potassium to sodium ratio is of greater importance than just the the lower intake of salt in regards to heart and general body functioning. A ratio of 4:1 is recommended. Sodium (NOT from table salt, restaurant or "Industrial" foods, but from natural sources such as celery and carrots) assists in the solubility of blood minerals, helps repair hardened arteries, is a vital component of the lymphatic system.
Avatar m tn Hey there & Welcome! Congrats on coming off the Subs! Subs tend to be a lot less predictable in terms of return of energy & sleep than methadone or other synthetics that store in bone & other tissues because it has a much more variable fat solubility ratio from person to person. This means that in one person who's on it for a year, the subs might not store as rapidly in tissue as another person who does it for the same amt. of time at the same dose.
Avatar m tn Karenmaria, Hi & Welcome. Naltrexone will not 'increase' endorphin production or stop cravings. It will block opiates that you might take after detox. They give it in tablet form or in a monthly injection called 'Vivitrol'. As eagle 101 mentions Subs & Fentanyl are rough kicks. However, Methadone (particularly long-acting Methadone called LAAM) has the longest half-life.
8520825 tn?1398511460 You shouldn't be quitting by yourself. If you really hate it, you can point out to your doctor that you don't have to take anything you don't want to, and that you'd rather have a proper schedule. Stopping too quickly could cause a flare up in symptoms. 1200 mg is actually higher than the recommended max dose, which is 800 mg/day, unless you're taking something else that speeds up its metabolism. Another drug might work better for you without feeling so zombifying.
Avatar f tn (1) Since cholesterol is required to make hormones, the cyclic changes in female hormone levels may affect the concentration or solubility of cholesterol in the bile. If the bile is weak (i.e. unable to keep excess cholesterol in solution for its disposal) then more cholesterol will come out of solution, producing sand, sludge or stones and lead to "gb attacks".
Avatar m tn Although doxycycline and minocycline attain comparable serum [meaning blood] levels, there are important differences in CSF [cerebrospinal fluid, meaning the fluid around the brain and spinal cord] and CNS [meaning central nervous system] concentrations. The high lipid [fat] solubility of minocycline may cause vestibular [meaning inner ear balance] side effects, limiting the administration of minocycline to 100 mg twice daily rather than 200 mg twice daily.
Avatar m tn The high lipid solubility of minocycline may cause vestibular [ear] side effects, limiting the administration of minocycline to 100 mg twice daily rather than 200 mg twice daily. Because of this, doxycycline (400 mg daily) remains the preferred antibiotic for treatment of Lyme neuroborreliosis. For patients for whom treatment fails, minocycline may be a therapeutic option [footnote omitted].